| Country: | JPN |
| Type: | National |
| Route: | 181 |
| Map Custom: | yes |
| Length Km: | 101.8 |
| Length Ref: | [1] |
| Established: | 18 May 1953 |
| Direction A: | North |
| Terminus A: | in Yonago |
| Direction B: | South |
| Terminus B: | in Tsuyama |
| Previous Type: | Route |
| Previous Route: | 180 |
| Next Type: | Route |
| Next Route: | 182 |
National Route 181 is a national highway of Japan connecting Tsuyama and Yonago in Japan, with a total length of 101.8 km (63.26 mi).