| Country: | JPN |
| Type: | National |
| Route: | 159 |
| Map Custom: | yes |
| Length Km: | 64.8 |
| Length Ref: | [1] |
| Established: | 1953 |
| Direction A: | North |
| Terminus A: | in Nanao, Ishikawa |
| Direction B: | South |
| Terminus B: | in Kanazawa, Ishikawa |
| Previous Type: | Route |
| Previous Route: | 158 |
| Next Type: | Route |
| Next Route: | 160 |
National Route 159 is a national highway of Japan connecting Nanao, Ishikawa and Kanazawa, Ishikawa in Japan, with a total length of 64.8km (40.3miles).