Janet Mary Lord Explained

Janet Mary Lord
Workplaces:	University of Birmingham University of Oxford
Alma Mater:	Oxford Brookes University Aston University
Thesis Title:	The effect of oral-hypoglycaemic drugs and obesity on insulin receptor binding
Thesis Url:	https://publications.aston.ac.uk/id/eprint/10561/
Thesis Year:	1983

Janet Mary Lord is a British biologist who is a Professor of Immune Cell Biology at the University of Birmingham. Her research considers immunity in old age, with a focus on the decline of neutrophil function. She was made a Commander of the British Empire in the 2023 New Year Honours List.

Early life and education

Lord studied Human Biology at Oxford Brookes University, then moved to Aston University for her doctoral research, where she studied the impact of hypoglycaemic drugs and obesity on insulin receptor binding.^[1] She joined the University of Oxford as a research fellow.^[2]

Research and career

Lord researches the effect of ageing on immune function, and how this impacts the ability of older people to resolve inflammation. Her research has shown that exercise helps to slow the ageing process.^{[3] [4]} She showed that older adults have neutrophils which aren't as effective (lower phagocytosis, chemotaxis and NET generation) and have high levels of cortisol. Elevated levels of cortisol have a negative impact on ageing, including increasing muscle and bone loss and raising blood pressure.^[5] Lord showed that defects in neutrophil chemotaxis can also be corrected by statins. Lord joined the University of Birmingham early in her career, first as a Royal Society University Research Fellow and then professor in 2004.^[6]

Lord is Director of the Medical Research Council Versus Arthritis Centre for musculoskeletal ageing research.^[7] The centre is located in the Queen Elizabeth Hospital Birmingham. She was a member of the Academy of Medical Sciences Healthy Ageing Forum,^[8] a group which looked to understand ageing research and priorities the most effective intervention.^{[9] [10]}

Lord is part of the CARINA (CAtalyst Reducing ImmuNe Ageing) Network.^[11] The network looks to understand the immune system throughout human life.^[12]

Awards and honours

• 2013 British Society for Research into Ageing Lord Cohen Medal^[13]
• 2015 Elected Fellow of the Academy of Medical Sciences^[14]
• 2022 Elected to the Order of the British Empire^[15]

Notes and References

1. The effect of oral-hypoglycaemic drugs and obesity on insulin receptor binding . Aston University . 1983 . phd . en-GB . Janet M. . Lord.
2. Web site: brownda . 2019-07-30 . Professor Janet Lord . 2022-12-31 . NIHR SRMRC – Surgical Reconstruction and Microbiology Research Centre . en-GB.
3. Web site: 2013-09-07 . How to live longer – the experts' guide to ageing . 2022-12-31 . the Guardian . en.
4. Web site: Gilbert . Yvonne . 2018-03-08 . Exercise can slow the ageing process – a professor explains how . 2022-12-31 . The Faculty of Sport and Exercise Medicine . en.
5. Web site: BBC World Service – CrowdScience, How can I live a longer life?, How does exercise help us in old age? . 2022-12-31 . BBC . en-GB.
6. Web site: Janet Lord . 2022-12-31 . University of Birmingham . en-GB.
7. Web site: Top-50 Women Longevity Leaders . 2022-12-31 . Aging Analytics Agency . en.
8. Web site: Healthy ageing FORUM conference steering committee .
9. Web site: Healthy ageing conference The Academy of Medical Sciences . 2022-12-31 . acmedsci.ac.uk.
10. Web site: Healthy ageing Royal Society . 2022-12-31 . royalsociety.org.
11. Web site: CARINA Governance British Society for Immunology . 2022-12-31 . www.immunology.org.
12. Web site: CARINA Network British Society for Immunology . 2022-12-31 . www.immunology.org.
13. Web site: Janet M. Lord . 2022-12-31 . The Conversation . en.
14. Web site: Professor Janet Lord The Academy of Medical Sciences . 2022-12-31 . acmedsci.ac.uk.
15. Web site: Immunologists recognised in New Year's Honours List British Society for Immunology . 2022-12-31 . www.immunology.org.