Jane Visvader Explained

Workplaces:	Walter and Eliza Hall Institute of Medical Research Salk Institute
Alma Mater:	University of Adelaide
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Jane Visvader is a scientist specialising in breast cancer research who works for the Walter and Eliza Hall Institute in Melbourne, Australia. She is the joint head of the Breast Cancer Laboratory with Geoff Lindeman.^[1]

Education

Visvader holds a PhD in Biochemistry from the University of Adelaide having studied structure and function of citrus exocortis viroid^[2]

Career and research

After her PhD ^[3] in the Department of Biochemistry at the University of Adelaide, she was a postdoctoral researcher with Inder Verma (Salk Institute, San Diego) and Jerry Adams (Walter and Eliza Hall Institute (WEHI)).^[4] She worked at the Children's Hospital/Harvard Medical School in Boston before returning to Victoria in 1997 to establish a Breast Cancer Laboratory at WEHI.^[5] .

Visvader has published work investigating the role of cells of origin in cancer^[6] and in particular focuses on the role of stem cells,^{[7] [8]} which she believes may be a key to understanding breast cancer.^[9]

Visvader is a board member of the Cancer Council Victoria, Medical & Scientific Committee.^[10]

Patents

Visvader is a named inventor on five patents relating to cancer research focused on stem cell isolation and diagnostics.^[11]

• Method Of Cell Isolation, Application number: 20080038230
• Differentiation and/or proliferation modulating agents and uses therefor, Application number: 20060166917
• Novel phosphoprotein, Application number: 20060148032
• Method of diagnosis and treatment and agents useful for same, Application number: 20050048528
• Differentiation and/or proliferation modulating agents and uses therefor, Application number: 20030175971

Awardsa and recognition

• 2008 GlaxoSmithKline Award for Research Excellence (Joint with Geoff Lindeman)^[12]
• 2012 Fellow of the Australian Academy of Science^[13]
• 2014 Royal Society of Victoria Research Medal for Scientific Excellence in Biomedical & Health Sciences.^[14]
• 2016 National Health and Medical Research Council Elizabeth Blackburn Fellowship ^[15]
• 2016 Lemberg Medal, Australian Society for Biochemistry and Molecular Biology ^[16]
• 2016 Fellowship of the Australian Academy of Health and Medical Sciences ^[17]
• 2017 Victoria Prize for Science & Innovation (Joint with Geoff Lindeman) ^[18]
• 2020 Fellow of the Royal Society (FRS).^[19]
• 2022 Ziskin Prize, Stand Up to Cancer (joint award) ^[20]
• 2022 Fellow of the American Society of Cancer Research (AACR) Academy ^[21]

Selected publications

• Rios . AC. Fu . NY. Lindeman . GJ. Visvader . JE. In situ identification of bipotent stem cells in the mammary gland. Nature. 20 February 2014 . 506. 322-7. 24463516.
• Nolan E, Vaillant F, Branstetter D, Pal B, Giner G, Whitehead L, Lok SW, Mann GB, Rohrbach K, Huang LY, Soriano R, Smyth GK, Dougall WC, Visvader JE* and Lindeman GJ*. (2016) RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers. Nat Med. 2016 Jun 20. doi: 10.1038/nm.4118. PMID: 27322743 equal senior author
• Fu NY, Rios AC, Pal B, Law C, Jamieson P, Liu R, Vaillant F, Jackling F, Liu KH, Smyth GK, Lindeman GJ, Ritchie ME, and Visvader JE. Identification of quiescent and spatially-restricted mammary stem cells that are hormone responsive. Nature Cell Biol. 2017 19(3):164-176 PMID: 28192422
• Rios AC, Capaldo BD, Vaillant F, Pal B, van Ineveld R, Dawson CA, Chen Y, Nolan E, Fu NY; 3DTCLSM Group, Jackling FC, Devi S, Clouston D, Whitehead L, Smyth GK, Mueller SN, Lindeman GJ, Visvader JE. Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging. Cancer Cell. 2019 35(4), 618-632 PMID: 31185217
• Dawson CA, Pal B, Vaillant F, Gandolfo LC, Liu Z, Bleriot C, Ginhoux F, Smyth GK, Lindeman GJ, Mueller SN, Rios AC, Visvader JE. Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling. Nature Cell Biol. 2020 22(5), 546-558. PMID: 32341550
• Pal B, Chen Y, Vaillant F, Capaldo BD, Joyce R, Song X, Bryant VL, Penington JS, Di Stephano L, Tubau Ribera N, Wilcox S, Mann, GB, kConFab, Papenfuss AT, Lindeman GJ, Smyth GK*, Visvader JE*. A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast. EMBO J. 2021 40(11): e107333 PMID: 33950524 *equal senior authors

Notes and References

1. Web site: Professor Jane Visvader . 2014-08-14.
2. Web site: Structure and function of citrus exocortis viroid / by Jane Ellen Visvader. - Version details - Trove . Trove.nla.gov.au . 2006-12-28. 2014-08-14.
3. https://www.centenary.org.au/people/professor-jane-visvader/
4. Web site: News | Royal Society of Victoria | Promoting Science and Science Education . Royalsocietyvictoria.org.au . 2014-08-14.
5. Web site: News | Royal Society of Victoria | Promoting Science and Science Education . Royalsocietyvictoria.org.au . 2014-08-14.
6. 10.1038/nature09781. 21248838. Cells of origin in cancer. Nature. 469. 7330. 314–322. 2011. Visvader. Jane E.. 2011Natur.469..314V. 4418009.
7. 10.1038/nature12948. 24463516. In situ identification of bipotent stem cells in the mammary gland. Nature. 506. 7488. 322–327. 2014. Rios. Anne C.. Fu. Nai Yang. Lindeman. Geoffrey J.. Visvader. Jane E.. 2014Natur.506..322R. 205237171.
8. 10.1016/j.stem.2012.05.007. 22704512. Cancer Stem Cells: Current Status and Evolving Complexities. Cell Stem Cell. 10. 6. 717–728. 2012. Visvader. Jane E.. Lindeman. Geoffrey J.. free.
9. Giovanni Valenti . Interview with Jane Visvader: stem cells in the breast | Europe's stem cell hub . Nature . 439 . 7072 . 84–88 . 10.1038/nature04372 . 16397499 . 2012-01-11 . 2662840 . 2014-08-14.
10. https://www.cancervic.org.au/about/governance/executive-committee
11. Web site: Patents by Inventor Jane Visvader - Justia Patents Database . Patents.justia.com . 2014-08-14.
12. Web site: GSK Alumni Members. 2021-02-09.
13. Web site: Fellowship list - Australian Academy of Science . Science.org.au . 2014-08-14.
14. Web site: News | Royal Society of Victoria | Promoting Science and Science Education . Royalsocietyvictoria.org.au . 2014-08-14.
15. Web site: Top NHMRC research recognised. 2021-02-09.
16. Web site: THE 2016 LEMBERG MEDAL: JANE VISVADER . 9 February 2021.
17. Web site: AAHMS announces its second scientific meeting and induction of new fellows. Australian Academy of Health and Medical Sciences . 14 October 2016.
18. Web site: Professor Jane Visvader&Professor Geoffrey Lindeman 2017 Victoria Prize for Science & Innovation. 2021-02-09.
19. Web site: Jane Visvader. Royal Society. 20 September 2020.
20. https://www.wehi.edu.au/researcher/jane-visvader/
21. https://www.wehi.edu.au/researcher/jane-visvader/