James Kirklin Explained

James K. Kirklin
Birth Place:Rochester, Minnesota, US
Education:Harvard Medical School
Profession:Heart surgeon
Work Institutions:University of Alabama at Birmingham, US
Known For:
Birth Date:1947
Occupation:Cardiac surgeon
Relations:John W. Kirklin (Father)
Research Field:

James K. Kirklin (born 1947 in Rochester, Minnesota)[1] is an American cardiac surgeon who has made significant scientific and surgical contributions in the fields of heart transplantation and mechanical circulatory support devices to assist the pumping action of the heart.[2] He was formerly Professor of Surgery (1987-2022),[3] Director of the Division of Cardiothoracic Surgery (2006-2016),[4] Director of the James and John Kirklin Institute for Research in Surgical Outcomes (KIRSO) (2016–2022),[5] [6] and Co-Director of Comprehensive Cardiovascular Center (2011-2017)[7] at the University of Alabama at Birmingham (UAB). While at UAB, he held the UAB Cardiovascular Research Chair (1998-2006), the John Kirklin Chair of Cardiovascular Surgery (2006-2017), and the James Kirklin Chair of Cardiothoracic Surgery (2017-2022).[8]

Biography

Kirklin is the son of the late heart surgery pioneer John W. Kirklin.[1] He graduated from Ohio State University in 1969, where he was an All-American diver.[9] [10] He received his MD from Harvard Medical School in 1973 as a member of the Alpha Omega Alpha academic honor society.[9] [11] Subsequently, he completed general and cardiothoracic surgery residencies at Massachusetts General Hospital in 1978 where he was Chief Resident, and pursued additional training at Boston Children's Hospital in 1979 and UAB School of Medicine, where he completed his training in 1981. He was appointed Assistant Professor of Surgery at UAB in 1981, Director of Cardiac Transplantation in 1986, Professor of Surgery in 1987, and in 2006 was named Director of the Division of Cardiothoracic Surgery.[8] Kirklin's surgical expertise included surgery for congenital heart disease, heart transplantation, and mechanical circulatory support pumps. In 2012, Kirklin and his colleagues developed the first Children's Hospital pediatric cardiac surgical unit in the state of Alabama. In 2017, at the age of 70, he retired from clinical surgery to direct the Kirklin Institute for Research in surgical outcomes.[12] [13] Kirklin retired from UAB in 2022 at the age of 75 to become President of Kirklin Solutions, Inc., a UAB health technology start-up company (January 2023).

Scientific work and surgical highlights

Kirklin and his colleagues at UAB pioneered the development of multi-institutional collaborative outcomes research in pediatric and adult heart transplantation and mechanical circulatory support.[14] [15] In 2007, he was the first surgeon to bridge an infant with failing single ventricular heart to successful heart transplantation, with a longer term pediatric heart assist device called the Berlin Heart ventricular assist device.[16] In 2011, he was the first surgeon in North America to implant the HVAD continuous flow ventricular assist device in a child.[17] This nine-year-old girl was supported for 60 days and she then underwent successful cardiac transplantation.[17] In 2014, Kirklin was the first surgeon in North America to implant the Eva Heart continuous flow ventricular assist device.[18] [19] In 2015, Kirklin led the surgical team that implanted the Berlin Heart on the youngest baby (17 days old) to receive extended (greater than 1 month) mechanical circulatory support (136 days) before undergoing successful heart transplantation.[20] [21]

Kirklin and his colleagues at UAB established the Cardiac Transplant Research Database in 1990, which generated the first multi-institutional collaborative research in heart transplantation, producing numerous seminal publications over a 20-year span.[22] In 1993, Kirklin and his UAB research group initiated the Pediatric Heart Transplant Study Group, which became the Pediatric Heart Transplant Society (PHTS), and continues to lead the field in multi-instuitional studies.[23] In 2013, Kirklin was honored as a Founding Father of the PHTS. Kirklin's research group developed an international database platform for mechanical circulatory support (IMACS) within the International Society for Heart and Lung Transplantation (ISHLT) in 2012, and created and direct a global database for the World Society for Pediatric and Congenital Heart Surgery (WSPCHS) since 2017.[24]

Kirklin was Principal Investigator of the $15 million NIH-funded national Registry for Mechanically Assisted Circulatory Support (INTERMACS) from 2006 to 2017. Kirklin is Past President of the International Society for Heart and Lung Transplantation (2009-2010) and President (2022) of the World Society for Pediatric and Congenital Heart Surgery. In April 2016, UAB established the James and John Kirklin Institute for Research in Surgical Outcomes.[25]

Kirklin was first author of the textbook of Heart Transplantation in 2002,[26] co-authored the fourth edition of the textbook of heart surgery Cardiac Surgery in 2013,[27] [28] and co-edited the book Mechanical Circulatory Support: A Companion to Braunwald's Heart Disease, 2nd Edition in 2019.[29] He served as Editor of the Journal of Heart and Lung Transplantation from 2000–2009,[30] and he was principal editor of the ISHLT Monograph Series (2006-2021).[31] In 2014 Kirklin was the first recipient of the ISHLT Distinguished Educator Award.[2] He has authored over 500 scientific publications. In 2020 Kirklin received the International Society for Heart and Lung Transplantation Lifetime Achievement Award.[32] In 2021 he received the Pediatric Heart Transplant Society Lifetime Achievement Award.[33]

Awards and honors

Among the honors Kirklin has received are:

References

Notes and References

  1. Web site: John W. Kirklin Is Dead at 86; Innovator in Cardiac Surgery - New York Times. 30 April 2004. The New York Times. 11 September 2014.
  2. Web site: International Society for Heart & Lung Transplantation Reveals 2014 Award Winners. Prweb.com. 2 October 2017.
  3. News: Haygood . Sheldon . James Kirklin, the doctor with a heart of gold . wbrc . 19 February 2019 . en.
  4. Web site: UAB Cardiothoracic Surgery Annual Report 2015-16 UAB Medicine Cardiothoracic Surgery 2015/16 Annual. Joomag.com. 2 October 2017.
  5. Web site: Rohan . Alicia . UAB to open institute for surgical outcomes research honoring John and James Kirklin . UAB News . 10 June 2016.
  6. Web site: UAB - School of Medicine - Surgery - KIRSO Home. Uab.edu. dead. 26 September 2019. 26 September 2019. https://web.archive.org/web/20190926143443/https://www.uab.edu/medicine/surgery/research/resources/kirso/about-kirso.
  7. Web site: Buchanan . Charles . 2012 . Transforming Treatment - The Comprehensive Cardiovascular Center. UAB Medicine Magazine. 26 September 2019.
  8. Web site: UAB - School of Medicine - Surgery - Kirklin, James K., M.D.. Tricia. Green. Uab.edu. 2 October 2017. 3 October 2017. https://web.archive.org/web/20171003025739/http://www.uab.edu/medicine/surgery/cardiothoracic/faculty/kirklin. dead.
  9. Web site: James Kirklin - CTSNet. Ctsnet.org. 11 September 2014.
  10. Web site: OhioStateBuckeyes.com :: The Ohio State University official athletic site. Ohiostatebuckeyes.com. 2 October 2017.
  11. Web site: Alpha Omega Alpha - About Alpha Omega Alpha. Alphaomegaalpha.org. 2 October 2017.
  12. Web site: History Birmingham, Alabama (AL) - Children's of Alabama. Childrensal.org. 2 October 2017.
  13. Web site: Children's of Alabama . Childrensal.org . 2 October 2017.
  14. Web site: UAB - Interagency Registry for Mechanically Assisted Circulatory Support - Investigators. Uab.edu. dead. https://web.archive.org/web/20190926151442/https://www.uab.edu/medicine/intermacs/. 26 September 2019. 26 September 2019.
  15. Web site: Dr. James Kirklin to assume late father's post at UAB - Birmingham Business Journal. Birmingham Business Journal. 11 September 2014.
  16. 10.1016/j.jtcvs.2008.02.044 . 19154881 . Successful cardiac transplant after Berlin Heart bridge in a single ventricle heart: Use of aortopulmonary shunt as a supplementary source of pulmonary blood flow . The Journal of Thoracic and Cardiovascular Surgery . 137 . 1 . e40–2 . 2009 . Pearce . F. Bennett . Kirklin . James K . Holman . William L . Barrett . Cindy S . Romp . Robb L . Lau . Yung R . free .
  17. 10.1016/j.athoracsur.2011.08.060 . 22364990 . Implantation of the Heart Ware HVAD in a Child After a Recent Thromboembolic Stroke . The Annals of Thoracic Surgery . 93 . 3 . 977–8 . 2012 . Kirklin . James K . Pearce . F. Bennett . Pamboukian . Salpy V . Alten . Jeffrey A . Borasino . Santiago . Carlo . Waldemer F . Holman . William L . free .
  18. Web site: UAB patient becomes first outside Japan with new heart implant. Lauren. Walsh. Abc3340.com. 10 February 2015 . 2 October 2017.
  19. Web site: Hayden Man is First Outside Japan to Receive New Heart Implant - UAB Medicine News - UAB Medicine. Greer. Tyler. 11 February 2015. Uabmedicine.org. 26 September 2019.
  20. Web site: Auburn, LSU families brought together through tragedy - ESPN Video. Espn.com. 2 October 2017.
  21. Web site: Auburn heart transplant recipient meets donor family, families encourage community to donate life. Oanow.com. 7 April 2016 . 2 October 2017.
  22. Web site: UAB - Department of Surgery - James K. Kirklin, MD, Director. Kerry Gorelick. Uab.edu. 11 September 2014. 30 October 2014. https://web.archive.org/web/20141030040510/http://www.uab.edu/medicine/surgery/cardiothoracic/faculty/kirklin. dead.
  23. Web site: UAB - SOM - Pediatric Heart Transplant Study (PHTS) - Home. Uab.edu. 11 September 2014.
  24. Web site: World Society for Pediatric and Congenital Heart Surgery. 26 September 2019. World Society for Pediatric and Congenital Heart Surgery. 26 September 2019.
  25. Web site: UAB creates new surgical outcomes institute in honor of Kirklin family. Alexander. Alan. 16 June 2016. www.bizjournals.com. 8 February 2019.
  26. 10.1056/NEJM200212263472620 . Heart Transplantation. By James K. Kirklin, James B. Young, and David C. McGiffin. 883 pp., illustrated. New York, Churchill Livingstone, 2002. $229. 0-443-07655-3. New England Journal of Medicine . 347 . 26 . 2175–6 . 2002 . Deng . Mario C .
  27. Book: Kirklin/Barratt-Boyes Cardiac Surgery, Expert Consult - Online and Print (2 ... - Nicholas T. Kouchoukos, Eugene H. Blackstone, Frank L. Hanley, James K. Kirklin - Google Books. 11 September 2014. 978-1416063919. Nicholas t. Kouchoukos. MD. Eugene h. Blackstone. MD. Frank l. Hanley. MD. James k Kirklin. MD. 2012-10-26. Elsevier Health Sciences .
  28. Web site: James Kirklin, MD, Cardiac Surgery Author – Elsevier AuthorsElsevier Authors . Elsevier Authors . 11 September 2014.
  29. Web site: Mechanical Circulatory Support: A Companion to Braunwald's Heart Disease - 9780323566995 US Elsevier Health Bookshop. www.us.elsevierhealth.com. 2019-09-26.
  30. Web site: ISHLT: The International Society for Heart & Lung Transplantation. Ishlt.org. 2 October 2017. 1 October 2017. https://web.archive.org/web/20171001020116/http://www.ishlt.org/boardsAndCommittees/jhltEditorial.asp. dead.
  31. Web site: ISHLT: The International Society for Heart & Lung Transplantation - Monograph Series . 2019-09-26 . ishlt.org.
  32. Web site: ISHLT: The International Society for Heart & Lung Transplantation - Lifetime Achievement . 2019-09-26 . ishlt.org. 17 May 2019 .
  33. Web site: Kirklin named inaugural recipient of the PHTS Lifetime Achievement Award.
  34. Web site: ISHLT: The International Society for Heart & Lung Transplantation - Past Presidents.
  35. Web site: Kirklin named William W. L. Glenn Lecturer by AHA - School of Medicine - Surgery | UAB. 3 May 2018 .
  36. Web site: ISHLT: The International Society for Heart & Lung Transplantation - Lifetime Achievement . live . https://web.archive.org/web/20180616202036/http://www.ishlt.org/grants-awards/lifetime-achievement . 2018-06-16 . ishlt.org.
  37. Web site: WSPCHS - Home . 2022-10-04 . www.wspchs.org.

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