| James John Thomas | |
| Office: | 40th Mayor of Columbus |
| Birth Date: | 1868 |
| Birth Place: | Wrexham, North Wales |
| Death Date: | August 6, 1947 |
| Term Start: | January 1, 1920 |
| Term End: | 1931 |
| Predecessor: | George J. Karb |
| Successor: | Henry W. Worley |
| Party: | Republican |
| Profession: | City Council member Mayor |
James John Thomas (1868 – August 6, 1947) was a Republican politician from the U.S. state of Ohio. He was the 40th mayor of Columbus, Ohio and the 36th person to serve in that office. He was elected on Tuesday, November 4, 1919 and defeated incumbent Democratic mayor George J. Karb. He served Columbus immediately after World War I and throughout the 1920s.
After three consecutive terms in office he was defeated in the 1931 mayoral election by Henry W. Worley.