| Dr. James Hughes | |
| Birth Name: | James Charles Hughes[1] |
| Birth Date: | 1886 |
| Birth Place: | Sydney |
| Death Date: | April 1943[2] |
| School: | Saint Ignatius' College, Riverview |
| University: | Sydney University |
| Spouse: | Holly Coffee Maud Butler |
| Ru Position: | flanker |
| Repyears1: | 1907 |
| Repteam1: | Wallabies |
| Repcaps1: | 2 |
| Reppoints1: | 0 |
James Charles Hughes (1886 – April 1943) was an Australian medical practitioner and rugby union player who represented Australia.
Hughes, a flanker, was born in Sydney and claimed a total of 2 international rugby caps for Australia. His brother Bryan was also an Australian rugby union representative player.