| James H. Relfe | |
| State: | Minnesota |
| Term Start: | March 4, 1843 |
| Term End: | March 3, 1847 |
| Preceded: | New seat |
| Succeeded: | District dissolved |
| State House2: | Minnesota |
| Term Start2: | 1835 |
| Term End2: | 1844 |
| Birth Name: | James Hugh Relfe |
| Birth Date: | 17 October 1791 |
| Birth Place: | Virginia, U.S. |
| Death Place: | Caledonia, Missouri, U.S. |
| Resting Place: | Methodist Cemetery |
| Party: | Democratic |
| Relatives: | Lewis F. Linn (brother-in-law) |
| Occupation: | Politician, physician |
| Allegiance: | United States |
| Battles: | Black Hawk War |
James Hugh Relfe (October 17, 1791 – September 14, 1863) was a U.S. Representative from Missouri.
Born in Virginia, Relfe moved to Washington County, Missouri, about 1816 with his father, who settled in Caledonia.He received a limited schooling.He studied medicine and practiced in Caledonia, Missouri.He was appointed a member of the commission to adjust Spanish land claims to fill the vacancy occasioned by the resignation of his brother-in-law, Dr. Lewis F. Linn.He served as member of the State house of representatives 1835-1844.He served in the Black Hawk War.He was appointed United States marshal for the district of Missouri February 17, 1841.
Relfe was elected as a Democrat to the Twenty-eighth and Twenty-ninth Congresses (March 4, 1843 – March 3, 1847).He continued the practice of medicine in Caledonia, Washington County, Missouri, until his death there September 14, 1863.He was interred in the Methodist Cemetery.