| James Griffin | |
| Number: | 22, 34 |
| Position: | Defensive back |
| Birth Date: | 7 September 1961 |
| Birth Place: | Camilla, Georgia, U.S. |
| Height Ft: | 6 |
| Height In: | 2 |
| Weight Lb: | 197 |
| College: | Middle Tennessee St. |
| Draftyear: | 1983 |
| Draftround: | 7 |
| Draftpick: | 193 |
| Pastteams: | |
| Statlabel1: | Interceptions |
| Statvalue1: | 19 |
| Statlabel2: | Fumble recoveries |
| Statvalue2: | 4 |
| Statlabel3: | Touchdowns |
| Statvalue3: | 3 |
| Pfr: | GrifJa20 |
James Victor Griffin (born September 7, 1961) is a former American football defensive back who played seven seasons in the National Football League (NFL). He played college football at the Middle Tennessee State University.