| James F. Brennan | |
| Office: | 29th Mayor of Somerville, Massachusetts |
| Term Start: | January 1968 |
| Term End: | January 1970 |
| Predecessor: | John R. Havican (acting) |
| Birth Date: | July 23, 1916 |
| Death Date: | July 27, 2002 |
| Death Place: | Ireland |
| Nationality: | American |
| Spouse: | Ruth L. McAvoy, d. September 8, 2002 |
| Children: | James F. Brennan, Jr.; Thomas M. Brennan |
James F. Brennan (July 23, 1916 – July 28, 2002) was a Massachusetts politician who served as the 29th Mayor of Somerville, Massachusetts.