| James E. DeGrange Sr. | |
| Birth Date: | 24 September 1949 |
| Birth Place: | Baltimore, Maryland, U.S. |
| Office2: | Anne Arundel County Council |
| Term Start2: | 1994 |
| Term End2: | 1998 |
| State Senate: | Maryland |
| District: | 32nd |
| Term Start: | January 13, 1999 |
| Term End: | January 9, 2019 |
| Predecessor: | C. Edward Middlebrooks |
| Successor: | Pamela Beidle |
| Party: | Democrat |
| Occupation: | Businessman |
James Edward DeGrange Sr. (born September 24, 1949) is an American politician from Maryland and a member of the Democratic Party. He completed his third term in the Maryland State Senate, representing Maryland's district 32 in Anne Arundel County, at the end of 2018.
DeGrange was born in Baltimore, Maryland, but grew up in Anne Arundel County. He graduated from Glen Burnie High School in 1968 and attended Anne Arundel Community College. He served in the United States Army Reserve from 1968 to 1974. He is the Vice-President of the DeGrange Lumber Company.
DeGrange's political career began with his service on the Maryland Lottery Commission, on which he served from 1991 to 1999. In 1994, he was elected to serve on the Anne Arundel County Council. After one term on the council, he ran for and won the district 32 seat in the State Senate. DeGrange sat on the Budget and Taxation Committee and served as Vice-Chair of the Executive Nominations Committee.
DeGrange currently lives in Baywood delaware.