| Honorific Prefix: | Yang Berbahagia Dato |
| James Chan Khay Syn | |
| Honorific Suffix: | PSBS |
| Native Name Lang: | zh-my |
| Order: | 4th Mayor of City of Kuching South |
| Term Start: | 4 June 2008 |
| Term End: | 31 August 2019 |
| Deputy: | Abang Affandi Abang Anuar Hilmy Othman |
| Predecessor: | Chong Ted Tsiung |
| Successor: | Wee Hong Seng |
| Birth Date: | 1 June 1950 |
| Spouse: | Catherine S'ng |
| Party: | Independent (IND) |
Dato James Chan Khay Syn (; born 1 June 1950) was the fourth Mayor of Council of the City of Kuching South.
Chan previously worked as General Manager of Harwood Timber Sdn Bhd, a subsidiary of the Sarawak Timber Industry Development Corporation (STIDC).[1]
Chan succeeded Chong Ted Tsiung, the third mayor of Kuching South City, who died on 3 August 2007. Chan was sworn in as mayor on 4 June 2008, before he could fully recover from his knee surgery.[2] Mayor Chan is known to be a "hands on" Mayor as he constantly visit sites and markets such as Stutong Market to understand the situation and problems faced by people.
In late 2018, it was announced that Chan's term, due to expire on 31 December 2018, was extended until 31 August 2019.[3]