| James A. Donohoe | |
| Office: | Chief Judge of the United States District Court for the District of Nebraska |
| Term Start: | 1948 |
| Term End: | 1956 |
| Predecessor: | Office established |
| Successor: | John Wayne Delehant |
| Office1: | Judge of the United States District Court for the District of Nebraska |
| Term Start1: | April 27, 1933 |
| Term End1: | February 26, 1956 |
| Appointer1: | Franklin D. Roosevelt |
| Predecessor1: | Joseph William Woodrough |
| Successor1: | Richard Earl Robinson |
| Birth Name: | James A. Donohoe |
| Birth Date: | 9 August 1877 |
| Birth Place: | O'Neill, Nebraska |
| Education: | Midland University (B.S.) read law |
James A. Donohoe (August 9, 1877 – February 26, 1956) was a United States district judge of the United States District Court for the District of Nebraska.
Born in O'Neill, Nebraska, Donohoe received a Bachelor of Science degree from Freemont Normal College (now Midland University) in Nebraska in 1898 and read law to enter the bar in 1905. He was in private practice in Nebraska from 1905 to 1933. He was a member of the Nebraska Senate (now the sole house of the Nebraska Legislature) from 1908 to 1909.
On April 15, 1933, Donohoe was nominated by President Franklin D. Roosevelt to a seat on the United States District Court for the District of Nebraska vacated by Judge Joseph William Woodrough. Donohoe was confirmed by the United States Senate on April 20, 1933, and received his commission on April 27, 1933. He served as Chief Judge from 1948 until his death on February 26, 1956.