| James August Comiskey | |
| Office: | Judge of the United States District Court for the Eastern District of Louisiana |
| Term Start: | March 4, 1967 |
| Term End: | June 15, 1975 |
| Appointer: | Lyndon B. Johnson |
| Predecessor: | Seat established by 80 Stat. 75 |
| Successor: | Morey Leonard Sear |
| Birth Name: | James August Comiskey |
| Birth Date: | 16 October 1926 |
| Birth Place: | New Orleans, Louisiana |
| Death Place: | New Orleans, Louisiana |
| Education: | Loyola University New Orleans (BA, JD) |
James August Comiskey (October 16, 1926 – February 1, 2005) was a United States district judge of the United States District Court for the Eastern District of Louisiana.
Born in New Orleans, Louisiana, Comiskey was in the United States Army during World War II, from 1944 to 1946. He received a Bachelor of Arts degree from Loyola University New Orleans in 1949 and a Juris Doctor from Loyola University New Orleans College of Law in 1951. He was in private practice in New Orleans from 1951 to 1967.
On January 16, 1967, Comiskey was nominated by President Lyndon B. Johnson to a new seat on the United States District Court for the Eastern District of Louisiana created by 80 Stat. 75. He was confirmed by the United States Senate on March 2, 1967, and received his commission on March 4, 1967. Comiskey served in that capacity until his resignation on June 15, 1975.
Comiskey was thereafter in private practice in New Orleans until his death in that city on February 1, 2005.