| Jakob Mathias Antonson Lothe | |
| Birth Date: | 14 November 1881 |
| Birth Place: | Lote, Norway |
| Residence: | Lote, Norway |
| Nationality: | Norwegian |
| Party: | Liberal Party of Norway (Norwegian: Venstre) |
| Alma Mater: | Volda lærarhøgskule |
| Profession: | Teacher |
| Occupation: | Politician |
Jakob Mathias Antonson Lothe (14 November 1881 – 17 June 1975) was a Norwegian politician for the Liberal Party.
He was born in Lote in Gloppen as a son of farmers Anton Jakobsen Lothe (1852–1932) and Anne Marie A. Røsæt (1853–1940).
He was a member of Gloppen municipal council between 1919 and 1928, except for a short period between 1923 and 1925. He was elected to the Norwegian Parliament from Sogn og Fjordane in 1925, and was re-elected on five occasions, with a spell as deputy representative during the term 1928 - 1930. However, he served most of that term as well, after regular representative Per Klingenberg Hestetun died.
Lothe was President of the Lagting, the former quasi-upper house of the parliament of Norway, from 1945 - 1954.