Jacquelyn S. Fetrow Explained

Order:15th
Office:President, Albright College /* waiting for President, Albright College to be created. */ -->
Office:15th President, Albright College
Term Start:2017
Term End:2024
Predecessor:Lex O. McMillan III
Birth Place:Pennsylvania
Known For:Computational biophysics
Credits:, which produces label "Notable credit(s)"; or by
Works:, which produces label "Works"; or by
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Spouse:Brian A. Kell

Jacquelyn S. (Jacque) Fetrow (born 1960) is a computational biologist and college administrator who served as the 15th president of Albright College.[1] Before serving as president she served as Provost, Vice President of Academic Affairs, and Professor of Chemistry at the University of Richmond in Richmond, Virginia.[2] Prior to that appointment, she served as Dean of the College at Wake Forest University in Winston-Salem, North Carolina.[3] She also co-founded GeneFormatics, Inc., for which she served as Director and Chief Scientific Officer for four years.

Early life and education

Fetrow is a native of Camp Hill, Pennsylvania.[4] Her mother, Mildred F. Fetrow, was a public school teacher in the West Shore School District, teaching kindergarten, first grade and second grade for many years.[5] Her father, David E. Fetrow, was a carpenter. He also worked as a truck salesman, real estate salesman, and office manager.

Fetrow attended Camp Hill public schools through twelfth grade, Albright College for her bachelor's degree (Biochemistry), and Penn State College of Medicine for a Ph.D. (Biological Chemistry), which she earned in 1986 working with George D. Rose.[6] [7] She did post-doctoral stints at the University of Rochester School of Medicine under the mentorship of Fred Sherman, and at the Whitehead Institute at Massachusetts Institute of Technology under the tutelage of Peter S. Kim.

Career

Fetrow worked at the University at Albany, SUNY, from 1990 to 1998, serving as assistant and then associate professor of biological sciences. She then accepted a position at The Scripps Research Institute. Technology that she helped develop at Scripps served as the foundation for GeneFormatics, Inc., the company that Fetrow co-founded and at which she served as Chief Scientific Officer and Director.[8] In August 2003 she was appointed Reynolds Professor of Computational Biophysics at Wake Forest University in the departments of Physics and Computer Science, and in January 2009 she was appointed as Dean of Wake Forest College. She moved to the University of Richmond to serve as Provost and Vice President of Academic Affairs at the University of Richmond in 2014.

In 2017 Fetrow was appointed president of her alma mater, Albright College.[9] Near the end of her initial five-year term the Albright board unanimously approved an additional five-year contract extension.[10] During her time as president, Albright's reputation and stature grew such that it reached #146 in the US News & World Report National Liberal Arts College rankings in 2023, up from 'uncategorized' (below #200) when she began her term as president.[11] She led the drive to right-size Albright's tuition structure in order to be more transparent and to align better with the higher-education market in Pennsylvania and the socioeconomic realities experienced by the college-age student population.[12] At the same time she led the establishment of the Advancing Lives Scholarships endowment to reduce the tuition gap experienced by returning sophomore, junior, and senior students.[13]

As part of efforts to diversify Albright's revenue streams, Fetrow brought to Albright's campus the highly regarded K-12 STEM spectrum of educational programming, originally called Science Research Institute, which has evolved into Total Experience Learning[14] [15] [16] and has been recognized by the United Nations.[17] She worked to bolster Albright's strategic vision as an anchor institution in the city of Reading by transitioning the college's Northeast Reading neighborhood into the Innovation Corridor, a destination and a community where residents live, work, learn and play.[18] Local, state and federal governments provided significant support for the development of that vision.[19] [20] [21] [22] [23] Using external funding, Albright installed the first public electric vehicle charging stations in the city of Reading in 2021.[24]

In April 2024, the Albright College faculty passed a vote of no confidence against President Fetrow.[25] In May 2024, Albright board chair Ron Scheese announced that Fetrow would step down from the presidency, effective May 31, 2024.[26]

Research

Fetrow was the first to describe the non-regular protein structure, omega loop, a structure she identified and studied for her doctoral dissertation (work published under the name Jacquelyn F. Leszczynski).[27] Her early research work involved the experimental analysis of these structures in the protein cytochrome c.[28] [29] [30]

Later, Fetrow's work turned to the classification of functional sites in protein structures, resulting in Fuzzy Functional Forms[31] and active site profiling.[32] This work formed the foundation for the company she co-founded, GeneFormatics. Subsequent development of the active site profiling technology[33] [34] was used to create the Peroxiredoxin Classification Index.[35] [36] [37] This technology has been used to cluster other superfamilies, including the enolases,[38] peroxiredoxins, cytochrome P450s,[39] and arsenate reductases,[40] into functionally relevant clusters.

Awards and honors

Selected publications

Notes and References

  1. News: Albright College Names Alumna Jacquelyn S. Fetrow as Its 15th President Albright College. 2016-10-28. Albright College. 2018-03-07.
  2. Web site: University of Richmond News. news.richmond.edu. 2018-03-07.
  3. Web site: Dean of the College Inside Higher Ed. insidehighered.com. 2018-03-07.
  4. News: Camp Hill native to lead Albright College in 2017. PennLive.com. 2018-03-07.
  5. Web site: Mildred F. "Millie" Fetrow's Obituary on Patriot-News. Patriot-News. 2018-03-07.
  6. Web site: George D. Rose. Johns Hopkins University. 3 June 2016 .
  7. News: New Albright president sworn in Reading Eagle - NEWS. Reading Eagle. 2018-03-07.
  8. Web site: The Business of Biotech. www.albright.edu. 2018-03-07.
  9. Web site: 2016-10-28 . Alumna Jacquelyn S. Fetrow Named 15th President of Albright College . 2024-06-09 . Albright College News . en-US.
  10. Web site: Adams . Heather . 2022-09-02 . Albright Board Unanimously Votes to Extend President Fetrow's Contract . 2024-06-09 . BCTV . en-US.
  11. Web site: Albright College - Profile, Rankings and Data . May 29, 2024 . US News Best Colleges.
  12. Web site: 2019-01-14 . Albright College to 'right-size' tuition . 2024-05-29 . Berks Regional News WFMZ.com . en.
  13. Web site: Advancing Lives Scholarship . 2024-05-29 . Albright College . en-US.
  14. Web site: 2020-02-07 . Science Research Institute expands to Albright College . 2024-05-29 . Berks Regional News WFMZ.com . en.
  15. Web site: Total Experience Learning . 2024-05-29 . Albright College . en-US.
  16. Web site: Tom . Rader . 2022-02-17 . Albright College Science Research Institute_3 . 2024-05-29 . WFMZ.com . en.
  17. Web site: Mekeel . David . 2023-01-25 . Albright College's Total Experience Learning institute is getting international attention . 2024-05-29 . Reading Eagle . en-US.
  18. Web site: Gonzalez . Lexi . 2024-03-26 . Spotlight on Innovation Corridor in Northeast Reading . 2024-05-29 . BCTV . en-US.
  19. Web site: Griffaton . Grace . 2022-11-15 . Albright College details plans for $3 million state grant . 2024-05-29 . WFMZ.com . en.
  20. Web site: Kostival . David . 2022-11-21 . Albright, Alvernia, RACC could each get $2M from Reading . 2024-05-29 . WFMZ.com . en.
  21. Web site: Kostival . David . 2023-06-22 . Berks County Commissioners authorize financing resolution for Albright College . 2024-05-29 . WFMZ.com . en.
  22. Web site: Lynch . Michelle . 2024-01-22 . State official tours northeast Reading area targeted for revitalization by Habitat for Humanity of Berks County . 2024-05-29 . Reading Eagle . en-US.
  23. Web site: 2024-03-15 . Houlahan secures $11.7M for 14 community organizations . 2024-05-29 . Berks Weekly.
  24. Web site: Kolodziej . Ellen . 2021-12-10 . Albright College is adding electric charging stations . 2024-05-29 . WFMZ.com . en.
  25. Web site: 25 April 2024 . Faculty votes no-confidence in Albright College president, provost .
  26. Web site: Albright College president Jacquelyn Fetrow resigns . 14 May 2024 .
  27. Leszczynski JF, Rose GD . Loops in globular proteins: a novel category of secondary structure . Science . 234 . 4778 . 849–55 . November 1986 . 3775366 . 10.1126/science.3775366 . 1986Sci...234..849L .
  28. Fetrow JS, Cardillo TS, Sherman F . Deletions and replacements of omega loops in yeast iso-1-cytochrome c . Proteins . 6 . 4 . 372–81 . 1989 . 2560195 . 10.1002/prot.340060404 . 25525703 .
  29. Murphy ME, Fetrow JS, Burton RE, Brayer GD . The structure and function of omega loop A replacements in cytochrome c . Protein Science . 2 . 9 . 1429–40 . September 1993 . 8401228 . 2142463 . 10.1002/pro.5560020907 .
  30. Mulligan-Pullyblank P, Spitzer JS, Gilden BM, Fetrow JS . Loop replacement and random mutagenesis of omega-loop D, residues 70-84, in iso-1-cytochrome c . The Journal of Biological Chemistry . 271 . 15 . 8633–45 . April 1996 . 8621494 . 10.1074/jbc.271.15.8633 . free .
  31. Fetrow JS, Skolnick J . Method for prediction of protein function from sequence using the sequence-to-structure-to-function paradigm with application to glutaredoxins/thioredoxins and T1 ribonucleases . Journal of Molecular Biology . 281 . 5 . 949–68 . September 1998 . 9719646 . 10.1006/jmbi.1998.1993 .
  32. Cammer SA, Hoffman BT, Speir JA, Canady MA, Nelson MR, Knutson S, Gallina M, Baxter SM, Fetrow JS . Structure-based active site profiles for genome analysis and functional family subclassification . Journal of Molecular Biology . 334 . 3 . 387–401 . November 2003 . 14623182 . 10.1016/j.jmb.2003.09.062 .
  33. Huff RG, Bayram E, Tan H, Knutson ST, Knaggs MH, Richon AB, Santago P, Fetrow JS . Chemical and structural diversity in cyclooxygenase protein active sites . Chemistry & Biodiversity . 2 . 11 . 1533–52 . November 2005 . 17191953 . 10.1002/cbdv.200590125 . 10339/16028 . 25066310 . free .
  34. Book: Fetrow JS . Active site profiling to identify protein functional sites in sequences and structures using the Deacon Active Site Profiler (DASP) . Current Protocols in Bioinformatics . Chapter 8 . 8.10.1–8.10.16 . July 2006 . 18428769 . 10.1002/0471250953.bi0810s14 . 978-0471250951 .
  35. Soito L, Williamson C, Knutson ST, Fetrow JS, Poole LB, Nelson KJ . PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family . Nucleic Acids Research . 39 . Database issue . D332–7 . January 2011 . 21036863 . 3013668 . 10.1093/nar/gkq1060 .
  36. Nelson KJ, Knutson ST, Soito L, Klomsiri C, Poole LB, Fetrow JS . Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis . Proteins . 79 . 3 . 947–64 . March 2011 . 21287625 . 3065352 . 10.1002/prot.22936 .
  37. Harper AF, Leuthaeuser JB, Babbitt PC, Morris JH, Ferrin TE, Poole LB, Fetrow JS . An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins . PLOS Computational Biology . 13 . 2 . e1005284 . February 2017 . 28187133 . 5302317 . 10.1371/journal.pcbi.1005284 . 2017PLSCB..13E5284H . free .
  38. Knutson ST, Westwood BM, Leuthaeuser JB, Turner BE, Nguyendac D, Shea G, Kumar K, Hayden JD, Harper AF, Brown SD, Morris JH, Ferrin TE, Babbitt PC, Fetrow JS . An approach to functionally relevant clustering of the protein universe: Active site profile-based clustering of protein structures and sequences . Protein Science . 26 . 4 . 677–699 . April 2017 . 28054422 . 5368075 . 10.1002/pro.3112 .
  39. Gober JG, Rydeen AE, Gibson-O'Grady EJ, Leuthaeuser JB, Fetrow JS, Brustad EM . Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation . ChemBioChem . 17 . 5 . March 2, 2016 . 394–397 . 26690878 . 5241096 . 10.1002/cbic.201500624.
  40. Rosen MR, Leuthaeuser JB, Parish CA, Fetrow JS . Isofunctional Clustering and Conformational Analysis of the Arsenate Reductase Superfamily Reveals Nine Distinct Clusters . Biochemistry . 59 . 44 . 4262–4284 . November 2, 2020 . 10.1021/acs.biochem.0c00651 . 33135415 . 226233138 .
  41. News: 19 Penn Staters honored with Alumni Fellow Award Penn State University. 2018-03-07.
  42. News: Alumni Awards Albright College. Albright College. 2018-03-07.
  43. Web site: Faculty Awards. www.albany.edu. 2018-03-07.

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