| Honorific Prefix: | The Most Excellent |
| Jacobo Fitz-James Stuart | |
| Birth Name: | Jacobo Fitz-James Stuart y Ventimiglia |
| Birth Date: | 3 January 1821 |
| Birth Place: | Palermo, Sicily |
| Death Place: | Madrid, Spain |
| Family: | House of Alba branch of Fitz-James Stuart |
Jacobo Fitz-James Stuart y Ventimiglia, 15th Duke of Alba, GE (3 June 1821, Palermo, Sicily - 10 July 1881, Madrid, Spain) was a Spanish nobleman. He was a brother-in-law of Napoleon III through his wife, sister of Empress Eugenie.
He was the son of Carlos Miguel Fitz-James Stuart, 14th Duke of Alba and Rosalia Ventimiglia dei Principi di Grammonte. He married at Madrid, on 14 February 1848 María Francisca Portocarrero-Palafox y KirkPatrick, 12ª Duchess of Peñaranda de Duero and daughter of Cipriano de Palafox y Portocarrero. They had three children:
The co-lateral titles of this 15 Duke of Alba were: