| Birth Date: | 5 February 1937 |
| Birth Place: | Big Spring, Texas, U.S. |
| Height Ft: | 6 |
| Height In: | 2 |
| Weight Lbs: | 210 |
| Position: | Running back, placekicker |
| College: | TCU |
| Draftyear: | 1960 |
| Draftround: | 1 |
| Draftpick: | 6 |
| Afldraftyear: | 1960 |
| Afldraftround: | 1 Pick: First Selections (by the Denver Broncos) |
| Number: | 30 |
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| Pfr: | S/SpikJa00 |
Jack Erwin Spikes (born February 5, 1937) is an American former professional football player who was a running back and placekicker in the American Football League (AFL). He played college football for the TCU Horned Frogs before playing for the AFL's Dallas Texans/Kansas City Chiefs, Houston Oilers, and the Buffalo Bills.
Spikes played a key role in professional football's longest championship game, the 1962 AFL championship game between the Texans and the Houston Oilers. Spikes' teammate Bill Hull intercepted the Oilers' George Blanda late in the first overtime. Hull's interception allowed the Texans to start the second overtime with two powerful runs by Spikes, to move the ball to the Oilers' 25-yard line, and Tommy Brooker kicked a field goal to give the Texans the win, 20–17.