| Jacaré Grande River | |
| Pushpin Map: | Brazil |
| Source1 Location: | Pará state |
| Mouth Coordinates: | -0.5661°N -50.7819°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
| Tributaries Right: | Aramá River |
The Jacaré Grande River (Portuguese: Rio Jacaré Grande) is a river in the Pará state of north-central Brazil. It is considered an extension of the Rio Pará distribution channel.
The Jacaré Grande River rises on the island of Marajó in the delta region where the Amazon and Tocantins rivers empty into the Atlantic Ocean.It is contained within the Marajó Archipelago Environmental Protection Area.