Jacalin-like lectin domain explained

Symbol:	Jacalin
Jacalin-like lectin domain
Pfam:	PF01419
Interpro:	IPR001229
Scop:	1jac

In molecular biology, the jacalin-like lectin domain is a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B-cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.

Database of jacalin like lectins and structure function relations.^[1] Proteins containing this domain include:

• Jacalin, a tetrameric plant seed lectin and agglutinin from Artocarpus heterophyllus (jackfruit), which is specific for galactose.^[2]
• Artocarpin, a tetrameric plant seed lectin from A. heterophyllus.^[3]
• Lectin MPA, a tetrameric plant seed lectin and agglutinin from Maclura pomifera (Osage orange).^[4]
• Heltuba lectin, a plant seed lectin and agglutinin from Helianthus tuberosus (Jerusalem artichoke).^[5]
• Agglutinin from Calystegia sepium (Hedge bindweed).^[6]
• Griffithsin, an anti-viral lectin from red algae (Griffithsia species).^[7]

Notes and References

1. Raval et al, "A database analysis of jacalin-like lectins: sequence–structure–function relationships" Glycobiology vol. 14 no. 12 pp. 1247–1263, 2004 http://glycob.oxfordjournals.org/content/14/12/1247.full.pdf
2. Jeyaprakash AA, Geetha Rani P, Banuprakash Reddy G, Banumathi S, Betzel C, Sekar K, Surolia A, Vijayan M . Crystal structure of the jacalin-T-antigen complex and a comparative study of lectin-T-antigen complexes . J. Mol. Biol. . 321 . 4 . 637–45 . August 2002 . 12206779 . 10.1016/S0022-2836(02)00674-5. 10.1.1.532.2424 .
3. Jeyaprakash AA, Srivastav A, Surolia A, Vijayan M . Structural basis for the carbohydrate specificities of artocarpin: variation in the length of a loop as a strategy for generating ligand specificity . J. Mol. Biol. . 338 . 4 . 757–70 . May 2004 . 15099743 . 10.1016/j.jmb.2004.03.040 . 10.1.1.530.4331 .
4. Lee X, Thompson A, Zhang Z, Ton-that H, Biesterfeldt J, Ogata C, Xu L, Johnston RA, Young NM . Structure of the complex of Maclura pomifera agglutinin and the T-antigen disaccharide, Galbeta1,3GalNAc . J. Biol. Chem. . 273 . 11 . 6312–8 . March 1998 . 9497359 . 10.1074/jbc.273.11.6312. free .
5. Bourne Y, Zamboni V, Barre A, Peumans WJ, Van Damme EJ, Rouge P . Helianthus tuberosus lectin reveals a widespread scaffold for mannose-binding lectins . Structure . 7 . 12 . 1473–82 . December 1999 . 10647178 . 10.1016/s0969-2126(00)88338-0. free .
6. Bourne Y, Roig-Zamboni V, Barre A, Peumans WJ, Astoul CH, Van Damme EJ, Rouge P . The crystal structure of the Calystegia sepium agglutinin reveals a novel quaternary arrangement of lectin subunits with a beta-prism fold . J. Biol. Chem. . 279 . 1 . 527–33 . January 2004 . 14561768 . 10.1074/jbc.M308218200 . free .
7. Ziolkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A . Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding . Structure . 14 . 7 . 1127–35 . July 2006 . 16843894 . 10.1016/j.str.2006.05.017 . 7126681 .