JZL195 explained
JZL195 is a potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the primary enzymes responsible for degrading the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.[1]
See also
Notes and References
- Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF . Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo . Proceedings of the National Academy of Sciences of the United States of America . 106 . 48 . 20270–5 . December 2009 . 19918051 . 2787168 . 10.1073/pnas.0909411106 . 2009PNAS..10620270L . free .