JZ-IV-10 explained

JZ-IV-10 is a piperidine derivative related to cocaine which acts as a highly potent serotonin–norepinephrine–dopamine reuptake inhibitor (also called SNDRI, or triple reuptake inhibitor).^[1] The eugeroic modafinil was used as a lead to fuel this compound's discovery.^{[2] [3]}

See also

• 1-Methyl-3-propyl-4-(p-chlorophenyl)piperidine
• N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate
• Nocaine

Notes and References

1. WO. 2005041875. Dopamine-, norepinephrine- and serotonin- transporter- selective heterocyclic compounds and their therapeutic applications. 2005-05-12. Georgetown University. Kozikowski. Alan P.. Zhou. Jia.
2. Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP . Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization . Journal of Medicinal Chemistry . 47 . 24 . 5821–4 . November 2004 . 15537337 . 1395211 . 10.1021/jm040117o .
3. He R, Kurome T, Giberson KM, Johnson KM, Kozikowski AP . Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors . Journal of Medicinal Chemistry . 48 . 25 . 7970–9 . December 2005 . 16335921 . 10.1021/jm050694s .