JWH-359 explained

JWH-359 is a dibenzopyran "classical" cannabinoid drug, which is a potent and selective CB₂ receptor agonist, with a K_i of 13.0 nM and selectivity of around 220 times for CB₂ over CB₁ receptors. It is related to other dibenzopyran CB₂ agonists such as JWH-133 and L-759,656 but with a chiral side chain which has made it useful for mapping the shape of the CB₂ binding site.^{[1] [2]} It was discovered by, and named after, John W. Huffman.

Notes and References

1. Huffman JW, Bushell SM, Joshi SN, Wiley JL, Martin BR . Enantioselective synthesis of 1-methoxy- and 1-deoxy-2'-methyl-delta8-tetrahydrocannabinols: new selective ligands for the CB2 receptor . Bioorganic & Medicinal Chemistry . 14 . 1 . 247–62 . January 2006 . 16165365 . 10.1016/j.bmc.2005.08.013 .
2. Marriott KS, Huffman JW . Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor . Current Topics in Medicinal Chemistry . 8 . 3 . 187–204 . 2008 . 18289088 . 10.2174/156802608783498014 .