JWH-307 explained

JWH-307 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. It is somewhat selective for the CB₂ subtype, with a K_i of 7.7 nM at CB₁ vs 3.3 nM at CB₂.^[1] It was discovered by, and named after, John W. Huffman. JWH-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012, initially in Germany.^{[2] [3]}

In the United States, CB₁ receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-307 are Schedule I Controlled Substances.

See also

• JWH-147

Notes and References

1. Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB₁ and CB₂ receptors. Bioorganic & Medicinal Chemistry Letters 2006; 16:5432-5435.
2. Ernst L, Krüger K, Lindigkeit R, Schiebel HM, Beuerle T . Synthetic cannabinoids in "spice-like" herbal blends: first appearance of JWH-307 and recurrence of JWH-018 on the German market . Forensic Science International . 222 . 1–3 . 216–22 . October 2012 . 22748479 . 10.1016/j.forsciint.2012.05.027 .
3. Kneisel S, Auwärter V . Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction . Journal of Mass Spectrometry . 47 . 7 . 825–35 . July 2012 . 22791249 . 10.1002/jms.3020 . 2012JMSp...47..825K .