JWH-210 explained

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB₁ and CB₂ receptors, with K_i values of 0.46 nM at CB₁ and 0.69 nM at CB₂. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower K_i) at CB₁ than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB₁ K_i 0.69 nM) and JWH-182 (CB₁ K_i 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB₁ K_i 1.2 nM).^[1] It was discovered by and named after John W. Huffman.

JWH-210 may be neurotoxic to animals when administered in high doses.^[2]

Legal status

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-210 are Schedule I Controlled Substances.

JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" synthetic cannabis products.^{[3] [4]} The substances JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.^[5]

As of October 2015 JWH-210 is a controlled substance in China.^[6]

See also

• JWH-081
• JWH-193
• JWH-398

Notes and References

1. Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR . 6 . Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists . Bioorganic & Medicinal Chemistry . 13 . 1 . 89–112 . January 2005 . 15582455 . 10.1016/j.bmc.2004.09.050 .
2. Cha HJ, Seong YH, Song MJ, Jeong HS, Shin J, Yun J, Han K, Kim YH, Kang H, Kim HS . 6 . Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210 . Biomolecules & Therapeutics . 23 . 6 . 597–603 . November 2015 . 26535086 . 4624077 . 10.4062/biomolther.2015.057 .
3. http://www.riksdagen.se/webbnav/index.aspx?nid=3911&bet=1999:58 Swedish Code of Statutes Regulation (2010:1086).
4. Web site: Swedish Code of Statutes Regulation (2010:1086). (pdf) . 2011-01-10 . https://web.archive.org/web/20110728111705/http://www.lagboken.se/files/SFS/2010/101086.PDF . 2011-07-28 . dead .
5. LVFS 2011:8
6. Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . China Food and Drug Administration . 27 September 2015 . Chinese . 1 October 2015 . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . dead .