JWH-185 explained

JWH-185 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the carbonyl-reduced derivative of related compound JWH-081. The binding affinity of JWH-185 for the CB₁ receptor is reported as K_i = 17 ± 3 nM.^[1]

In the United States, all CB₁ receptor agonists of the 3-(1-naphthylmethane)indole class such as JWH-185 are Schedule I Controlled Substances.

See also

• JWH-081
• JWH-184

Notes and References

1. Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR . 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor . Bioorg. Med. Chem. . 11 . 4 . 539–549 . 2003 . 12538019. 10.1016/s0968-0896(02)00451-0. 29107765 .