JWH-149 explained

JWH-149 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-pentyl analog of JWH-148. It is a potent but only moderately selective ligand for the CB₂ receptor, with a binding affinity of K_i = 0.73 ± 0.03 nM at this subtype, and more than six times selectivity over the CB₁ subtype.^[1]

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-149 are Schedule I Controlled Substances.

See also

• JWH-120
• JWH-122
• JWH-148
• JWH-193
• JWH-210
• JWH-398

Notes and References

1. Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR . 6 . Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists . Bioorganic & Medicinal Chemistry . 13 . 1 . 89–112 . January 2005 . 15582455 . 10.1016/j.bmc.2004.09.050 .