JWH-147 explained

JWH-147 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. It is somewhat selective for the CB₂ subtype, with a K_i of 11.0 nM at CB₁ vs 7.1 nM at CB₂.^[1] It was discovered and named after the renowned professor of organic chemistry John W. Huffman.

Legal status

In the United States, CB₁ receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-147 are Schedule I Controlled Substances.

JWH-147 was banned in Sweden on 1 October 2010 as harmful to health, after being identified as an ingredient in "herbal" synthetic cannabis products.^{[2] [3]}

See also

• JWH-030
• JWH-307

Notes and References

1. Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR . 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB₁ and CB₂ receptors . Bioorganic & Medicinal Chemistry Letters . 16 . 20 . 5432–5 . October 2006 . 16889960 . 10.1016/j.bmcl.2006.07.051 .
2. http://www.riksdagen.se/webbnav/index.aspx?nid=3911&bet=1999:58 Swedish Code of Statutes Regulation (2010:1086).
3. Web site: Swedish Code of Statutes Regulation (2010:1086). (pdf) . 2011-01-10 . https://web.archive.org/web/20110728111705/http://www.lagboken.se/files/SFS/2010/101086.PDF . 2011-07-28 . dead .