JWH-122 explained

JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is a methylated analogue of JWH-018. It has a K_i of 0.69 nM at CB₁ and 1.2 nM at CB₂.^[1]

In January 2015, over 40 people were reportedly sickened after eating a holiday bread called Rosca de reyes purchased at a bakery in Santa Ana, California, that was laced with JWH-122.^[2]

Legal status

Australia

JWH-122 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).^[3] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.

China

As of October 2015 JWH-122 is a controlled substance in China.^[4]

United States

In the United States, JWH-122 is a Schedule I Controlled Substance.^[5]

See also

• JWH-193
• JWH-210
• JWH-398
• List of JWH cannabinoids

Notes and References

1. Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR . 6 . Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists . Bioorganic & Medicinal Chemistry . 13 . 1 . 89–112 . January 2005 . 15582455 . 10.1016/j.bmc.2004.09.050 .
2. Web site: Tests Show Synthetic Drug Contaminated Holiday Bread from CA Bakery. 2015-02-02 . Food Safety News .
3. Web site: Poisons Standard . October 2015 . Federal Register of Legislation . The Australian Government .
4. Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . China Food and Drug Administration . 27 September 2015 . Chinese . 1 October 2015 . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . dead .
5. Web site: Controlled Substances . Diversion Control Division . U.S. Department of Justice, Drug Enforcement Division (DEA) .