JWH-048 explained

JWH-048 is a selective cannabinoid ligand, with a bindining affinity of K_i = 0.5 ± 0.1 nM for the CB₂ subtype, and more than 22 times selectivity over the CB₁.^[1]

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-048 are Schedule I Controlled Substances.

See also

• JWH-015
• JWH-018
• JWH-019
• JWH-073

References

1. Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR . Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding . Drug and Alcohol Dependence . 60 . 2 . 133–40 . 2000 . 10940540. 10.1016/S0376-8716(99)00152-0 .