JUNB explained

Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene.^{[1] [2]} Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Interactions

JUNB has been shown to interact with

• BRCA1,^[3] and
• SMAD3.^[4]

See also

• AP-1 (transcription factor)

Further reading

• Hsu JC, Bravo R, Taub R . Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration . Mol. Cell. Biol. . 12 . 10 . 4654–65 . 1992 . 1406655 . 360392 . 10.1128/MCB.12.10.4654.
• Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP . Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte . FEBS Lett. . 306 . 2–3 . 169–172 . 1992 . 1633872 . 10.1016/0014-5793(92)80992-P . 43460076 . free . 1992FEBSL.306..169Z .
• Mollinedo F, Vaquerizo MJ, Naranjo JR . Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes . Biochem. J. . 273(Pt 2) . 2. 477–9 . 1991 . 1899335 . 1149869 . 10.1042/bj2730477.
• Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R . Isolation of human cDNA clones of jun-related genes, jun-B and jun-D . Nucleic Acids Res. . 18 . 10 . 3047–3048 . 1990 . 2112242 . 330838 . 10.1093/nar/18.10.3047 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A . Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers . Genomics . 15 . 1 . 133–145 . 1993 . 8432525 . 10.1006/geno.1993.1021 .
• Phinney DG, Tseng SW, Ryder K . Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci . Genomics . 28 . 2 . 228–234 . 1996 . 8530030 . 10.1006/geno.1995.1135 .
• Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ . B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family . Oncogene . 11 . 11 . 2255–65 . 1996 . 8570175 .
• Neyns B, Vermeij J, Bourgain C, Vandamme B, Amfo K, Lissens W, DeSutter P, Hooghe-Peters E, DeGrève J . Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium . Oncogene . 12 . 6 . 1247–57 . 1996 . 8649827 .
• Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE . Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver . Proc. Natl. Acad. Sci. U.S.A. . 93 . 23 . 12908–12913 . 1996 . 8917518 . 24019 . 10.1073/pnas.93.23.12908 . 1996PNAS...9312908M . free .
• Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M . Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions . Mol. Cell. Biol. . 17 . 6 . 3094–102 . 1997 . 9154808 . 232162 . 10.1128/mcb.17.6.3094.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z . c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors . J. Biol. Chem. . 272 . 51 . 32163–32168 . 1998 . 9405416 . 10.1074/jbc.272.51.32163 . free .
• Venugopal R, Jaiswal AK . Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes . Oncogene . 17 . 24 . 3145–3156 . 1999 . 9872330 . 10.1038/sj.onc.1202237 . free .
• Li B, Tournier C, Davis RJ, Flavell RA . Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation . EMBO J. . 18 . 2 . 420–432 . 1999 . 9889198 . 1171136 . 10.1093/emboj/18.2.420 .
• Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF . Smads bind directly to the Jun family of AP-1 transcription factors . Proc. Natl. Acad. Sci. U.S.A. . 96 . 9 . 4844–4849 . 1999 . 10220381 . 21779 . 10.1073/pnas.96.9.4844 . 1999PNAS...96.4844L . free .
• Chen P, Flory E, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR . Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors . J. Biol. Chem. . 275 . 27 . 20382–20390 . 2000 . 10764760 . 10.1074/jbc.M001149200 . free .
• Echlin DR, Tae HJ, Mitin N, Taparowsky EJ . B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos . Oncogene . 19 . 14 . 1752–1763 . 2000 . 10777209 . 10.1038/sj.onc.1203491 . free .
• Verrecchia F, Pessah M, Atfi A, Mauviel A . Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation . J. Biol. Chem. . 275 . 39 . 30226–30231 . 2000 . 10903323 . 10.1074/jbc.M005310200 . free .
• Singh K, Camera E, Krug L, Basu A, Pandey RK, Munir S, Wlaschek M, Kochanek S, Schorpp-Kistner M, Picardo M, Angel P, Niemann C, Maity P, Scharffetter-Kochanek K . JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin . Nature . 9 . 1 . 2018 . 3425 . 30143626 . 10.1038/s41467-018-05726-z . 6109099 . 2018NatCo...9.3425S . free .

Notes and References

1. Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J . jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun . Cell . 59 . 6 . 987–997 . Feb 1990 . 2513129 . 10.1016/0092-8674(89)90755-1 . free .
2. Web site: Entrez Gene: JUNB jun B proto-oncogene .
3. Hu YF, Li R . JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction . Genes Dev. . 16 . 12 . 1509–17 . Jun 2002 . 12080089 . 186344 . 10.1101/gad.995502 .
4. Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF . Smads bind directly to the Jun family of AP-1 transcription factors . Proc. Natl. Acad. Sci. U.S.A. . 96 . 9 . 4844–9 . Apr 1999 . 10220381 . 21779 . 10.1073/pnas.96.9.4844. 1999PNAS...96.4844L . free .