JUB (gene) explained

Protein ajuba is a protein that in humans is encoded by the JUB gene.^{[1] [2]}

Function

JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.

Interactions

JUB (gene) has been shown to interact with Stratifin^[3] and SLC1A2.^[4]

Further reading

• Kanungo J, Pratt SJ, Marie H, Longmore GD . Ajuba, a Cytosolic LIM Protein, Shuttles into the Nucleus and Affects Embryonal Cell Proliferation and Fate Decisions . Mol. Biol. Cell . 11 . 10 . 3299–313 . 2000 . 11029037 . 14993 . 10.1091/mbc.11.10.3299 .
• Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D . The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba . Mol. Cell. Neurosci. . 19 . 2 . 152–64 . 2002 . 11860269 . 10.1006/mcne.2001.1066 . 45768895 .
• Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, Braga VM . The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin . J. Biol. Chem. . 278 . 2 . 1220–8 . 2003 . 12417594 . 10.1074/jbc.M205391200 . free .
• Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H . Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells . Cell . 114 . 5 . 585–98 . 2003 . 13678582 . 10.1016/S0092-8674(03)00642-1 . free .
• Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD . The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration . J. Cell Biol. . 168 . 5 . 813–24 . 2005 . 15728191 . 2171823 . 10.1083/jcb.200406083 .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD . The LIM Protein Ajuba Regulates Phosphatidylinositol 4,5-Bisphosphate Levels in Migrating Cells through an Interaction with and Activation of PIPKIα . Mol. Cell. Biol. . 25 . 10 . 3956–66 . 2005 . 15870270 . 1087706 . 10.1128/MCB.25.10.3956-3966.2005 .
• Feng Y, Longmore GD . The LIM Protein Ajuba Influences Interleukin-1-Induced NF-κB Activation by Affecting the Assembly and Activity of the Protein Kinase Cζ/p62/TRAF6 Signaling Complex . Mol. Cell. Biol. . 25 . 10 . 4010–22 . 2005 . 15870274 . 1087715 . 10.1128/MCB.25.10.4010-4022.2005 .
• Abe Y, Ohsugi M, Haraguchi K, Fujimoto J, Yamamoto T . LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis . FEBS Lett. . 580 . 3 . 782–8 . 2006 . 16413547 . 10.1016/j.febslet.2005.12.096 . free .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . free .
• Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA . TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours . Mol. Cell. Endocrinol. . 306 . 1–2 . 75–80 . 2008 . 19041365 . 10.1016/j.mce.2008.10.043 . 5456314 .

Notes and References

1. Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD . Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner . Mol Cell Biol . 19 . 6 . 4379–89 . Jun 1999 . 10330178 . 104397 . 10.1128/MCB.19.6.4379.
2. Web site: Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis).
3. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . Jun 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
4. Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D . The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba . Mol. Cell. Neurosci. . 19 . 2 . 152–64 . Feb 2002 . 11860269 . 10.1006/mcne.2001.1066 . 45768895 .