Jumping translocation breakpoint explained

Symbol:	JTB
Jumping translocation breakpoint protein (JTB)
Pfam:	PF05439
Interpro:	IPR008657

The jumping translocation breakpoint protein (JTB), also known as prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene.^{[1] [2]} It is an orphan receptor with unknown function.^[3]

The JTB family of proteins contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain. hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC). JTB has also been implicated in prostatic carcinomas.^[4]

Further reading

• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Wong N . Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression . J. Hepatol. . 38 . 3 . 298–306 . 2003 . 12586295 . 10.1016/S0168-8278(02)00412-9 . vanc. Chan A . Lee SW . 3 . Lam . E . To . KF . Lai . PB . Li . XN . Liew . CT . Johnson . PJ .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Zhang QH . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 . vanc. Ye M . Wu XY . 3 . Ren . SX . Zhao . M . Zhao . CJ . Fu . G . Shen . Y . Fan . HY .
• Platica O . PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells . Int. J. Oncol. . 16 . 5 . 1055–61 . 2000 . 10762645 . 10.3892/ijo.16.5.1055. vanc. Chen S . Ivan E . 3 . Lopingco . MC . Holland . JF . Platica . M .
• Yu W . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . vanc. Andersson B . Worley KC . 3 . Muzny . DM . Ding . Y . Liu . W . Ricafrente . JY . Wentland . MA . Lennon . G .
• Andersson B . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . vanc. Wentland MA . Ricafrente JY . 3 . Liu . W . Gibbs . RA .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein JTB

Notes and References

1. Hatakeyama S, Osawa M, Omine M, Ishikawa F . JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation . Oncogene . 18 . 12 . 2085–90 . Jun 1999 . 10321732 . 10.1038/sj.onc.1202510 . free .
2. Web site: Entrez Gene: JTB jumping translocation breakpoint.
3. Rousseau. Francois. Pan. Borlan. Fairbrother. Wayne J.. Bazan. J. Fernando. Lingel. Andreas. The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold. Journal of Molecular Biology. January 2012. 415. 1. 22–28. 10.1016/j.jmb.2011.10.048. 22079049.
4. Platica O, Chen S, Ivan E, Lopingco MC, Holland JF, Platica M . PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells . Int. J. Oncol. . 16 . 5 . 1055–61 . May 2000 . 10762645 . 10.3892/ijo.16.5.1055.