JPH1 explained
Junctophilin-1 is a protein that in humans is encoded by the JPH1 gene.[1] [2] [3]
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.
Further reading
- Takeshima H . Ryanodine receptor and junctional membrane structure. . Nippon Yakurigaku Zasshi . 121 . 4 . 203–10 . 2003 . 12777839 . 10.1254/fpj.121.203 . free .
- Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
- Nusbaum C, Mikkelsen TS, Zody MC, etal . DNA sequence and analysis of human chromosome 8. . Nature . 439 . 7074 . 331–5 . 2006 . 16421571 . 10.1038/nature04406 . 2006Natur.439..331N . free .
- Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Komazaki S, Ito K, Takeshima H, Nakamura H . Deficiency of triad formation in developing skeletal muscle cells lacking junctophilin type 1. . FEBS Lett. . 524 . 1–3 . 225–9 . 2002 . 12135771 . 10.1016/S0014-5793(02)03042-9 . 9826632 .
Notes and References
- Nishi M, Mizushima A, Nakagawara K, Takeshima H . Characterization of human junctophilin subtype genes . Biochem Biophys Res Commun . 273 . 3 . 920–7 . Sep 2000 . 10891348 . 10.1006/bbrc.2000.3011 .
- Takeshima H, Komazaki S, Nishi M, Iino M, Kangawa K . Junctophilins: a novel family of junctional membrane complex proteins . Mol Cell . 6 . 1 . 11–22 . Aug 2000 . 10949023 . 10.1016/S1097-2765(05)00005-5 . free .
- Web site: Entrez Gene: JPH1 junctophilin 1.
