JNJ-3792165 explained

Drug Name:	JNJ-3792165
Pubchem:	2747070
Chemspiderid:	2028519
Iupac Name:	1-[(2,6-dichlorophenyl)methyl]-5-methyl-N-(3-methylphenyl)pyrazole-3-carboxamide
C:	19
H:	17
Cl:	2
N:	3
O:	1
Stdinchi:	1S/C19H17Cl2N3O/c1-12-5-3-6-14(9-12)22-19(25)18-10-13(2)24(23-18)11-15-16(20)7-4-8-17(15)21/h3-10H,11H2,1-2H3,(H,22,25)
Stdinchikey:	SKUQQQWNGFTXFN-UHFFFAOYSA-N
Smiles:	CC1=CC(=CC=C1)NC(=O)C2=NN(C(=C2)C)CC3=C(C=CC=C3Cl)Cl

JNJ-3792165 is a chemical compound which acts as a small-molecule antagonist of the previously orphan receptor GPR139. It has been shown to modulate dopamine release in the brain via interaction with the Dopamine receptor D2, and increases the effect of morphine at the mu opioid receptor.^{[1] [2] [3] [4] [5]}

Notes and References

1. Nepomuceno D, Kuei C, Dvorak C, Lovenberg T, Liu C, Bonaventure P . Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro . Frontiers in Pharmacology . 9 . 157 . 2018 . 29599718 . 5863515 . 10.3389/fphar.2018.00157 . free .
2. Wang L, Lee G, Kuei C, Yao X, Harrington A, Bonaventure P, Lovenberg TW, Liu C . 6 . GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact . Frontiers in Neuroscience . 13 . 281 . 2019 . 30971885 . 6443882 . 10.3389/fnins.2019.00281 . free .
3. Vedel L, Nøhr AC, Gloriam DE, Bräuner-Osborne H . Pharmacology and function of the orphan GPR139 G protein-coupled receptor . Basic & Clinical Pharmacology & Toxicology . 126 . Suppl 6 . 35–46 . June 2020 . 31132229 . 7318219 . 10.1111/bcpt.13263 .
4. Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsøe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Bräuner-Osborne H, Gloriam DE, Hua T, Liu ZJ . 6 . Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139 . Cell Research . 32 . 2 . 210–213 . February 2022 . 34916631 . 8807744 . 10.1038/s41422-021-00591-w .
5. Pallareti L, Rath TF, Trapkov B, Tsonkov T, Nielsen AT, Harpsøe K, Gentry PR, Bräuner-Osborne H, Gloriam DE, Foster SR . 6 . Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139 . European Journal of Pharmacology . 943 . 175553 . March 2023 . 36736525 . 10.1016/j.ejphar.2023.175553 . 256562486 . free .