JNJ-10397049 explained

JNJ-10397049 is a potent and highly selective OX2 receptor antagonist. In animals, JNJ-10397049 was found to have sleep-promoting effects and to attenuate the reinforcing effects of ethanol.[1] [2]

Notes and References

  1. Dugovic C, Shelton JE, Aluisio LE, Fraser IC, Jiang X, Sutton SW, Bonaventure P, Yun S, Li X, Lord B, Dvorak CA, Carruthers NI, Lovenberg TW . 6 . Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat . The Journal of Pharmacology and Experimental Therapeutics . 330 . 1 . 142–51 . July 2009 . 19363060 . 10.1124/jpet.109.152009 . 5676758 .
  2. Shoblock JR, Welty N, Aluisio L, Fraser I, Motley ST, Morton K, Palmer J, Bonaventure P, Carruthers NI, Lovenberg TW, Boggs J, Galici R . 6 . Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement . Psychopharmacology . 215 . 1 . 191–203 . May 2011 . 21181123 . 10.1007/s00213-010-2127-x . 28874886 .

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