KDM5D explained

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene.^{[1] [2] [3]} KDM5D belongs to the alpha-ketoglutarate-dependent hydroxylases superfamily.

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.^[3]

Further reading

• Simpson E, Scott D, Chandler P . The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning . Annual Review of Immunology . 15 . 39–61 . 1997 . 9143681 . 10.1146/annurev.immunol.15.1.39 .
• Wolf U . The serologically detected H-Y antigen revisited . Cytogenetics and Cell Genetics . 80 . 1–4 . 232–5 . 1998 . 9678364 . 10.1159/000014986 . 2024-07-25 . 25908189 .
• Agulnik AI, Mitchell MJ, Lerner JL, Woods DR, Bishop CE . A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens . Human Molecular Genetics . 3 . 6 . 873–8 . June 1994 . 7524912 . 10.1093/hmg/3.6.873 .
• Wang W, Meadows LR, den Haan JM, Sherman NE, Chen Y, Blokland E, Shabanowitz J, Agulnik AI, Hendrickson RC, Bishop CE . Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein . Science . 269 . 5230 . 1588–90 . September 1995 . 7667640 . 10.1126/science.7667640 . 1995Sci...269.1588W . 1887/2988 . free .
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Research . 3 . 5 . 321–9, 341–54 . October 1996 . 9039502 . 10.1093/dnares/3.5.321 . free .
• Agulnik AI, Bishop CE, Lerner JL, Agulnik SI, Solovyev VV . Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven . Mammalian Genome . 8 . 2 . 134–8 . February 1997 . 9060413 . 10.1007/s003359900372 . 8099911 .
• Rufer N, Wolpert E, Helg C, Tiercy JM, Gratwohl A, Chapuis B, Jeannet M, Goulmy E, Roosnek E . HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation . Transplantation . 66 . 7 . 910–6 . October 1998 . 9798702 . 10.1097/00007890-199810150-00016 . free .
• Lau YF, Zhang J . Expression analysis of thirty one Y chromosome genes in human prostate cancer . Molecular Carcinogenesis . 27 . 4 . 308–21 . April 2000 . 10747295 . 10.1002/(SICI)1098-2744(200004)27:4<308::AID-MC9>3.0.CO;2-R . 23677925 .
• Shen P, Wang F, Underhill PA, Franco C, Yang WH, Roxas A, Sung R, Lin AA, Hyman RW, Vollrath D, Davis RW, Cavalli-Sforza LL, Oefner PJ . Population genetic implications from sequence variation in four Y chromosome genes . Proceedings of the National Academy of Sciences of the United States of America . 97 . 13 . 7354–9 . June 2000 . 10861003 . 16549 . 10.1073/pnas.97.13.7354 . 2000PNAS...97.7354S . free .
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC . The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes . Nature . 423 . 6942 . 825–37 . June 2003 . 12815422 . 10.1038/nature01722 . 2003Natur.423..825S . free .
• Agate RJ, Choe M, Arnold AP . Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches . Molecular Biology and Evolution . 21 . 2 . 384–96 . February 2004 . 14660691 . 10.1093/molbev/msh027 . free .
• Miklos DB, Kim HT, Miller KH, Guo L, Zorn E, Lee SJ, Hochberg EP, Wu CJ, Alyea EP, Cutler C, Ho V, Soiffer RJ, Antin JH, Ritz J . Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission . Blood . 105 . 7 . 2973–8 . April 2005 . 15613541 . 1350982 . 10.1182/blood-2004-09-3660 .
• Piper KP, McLarnon A, Arrazi J, Horlock C, Ainsworth J, Kilby MD, Martin WL, Moss PA . Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus . Biology of Reproduction . 76 . 1 . 96–101 . January 2007 . 16988213 . 10.1095/biolreprod.106.055426 . free .
• Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y . The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases . Cell . 128 . 6 . 1077–88 . March 2007 . 17320160 . 10.1016/j.cell.2007.02.017 . 14729302 . free .
• Lee MG, Norman J, Shilatifard A, Shiekhattar R . Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein . Cell . 128 . 5 . 877–87 . March 2007 . 17320162 . 10.1016/j.cell.2007.02.004 . 6519228 . free .

Notes and References

1. Froggatt P . The foundation of the "Inst" medical department and its association with the Belfast Fever Hospital . The Ulster Medical Journal . 45 . 2 . 107–45 . Feb 1977 . 795123 . 2385577 .
2. Kent-First MG, Maffitt M, Muallem A, Brisco P, Shultz J, Ekenberg S, Agulnik AI, Agulnik I, Shramm D, Bavister B, Abdul-Mawgood A, VandeBerg J . Gene sequence and evolutionary conservation of human SMCY . Nature Genetics . 14 . 2 . 128–9 . October 1996 . 8841177 . 10.1038/ng1096-128 . 23054699 .
3. Web site: Entrez Gene: JARID1D jumonji, AT rich interactive domain 1D.