| Iurie Osipenco | |
| Birth Date: | 1974 7, df=yes |
| Birth Place: | Hîncești, Moldavian SSR, Soviet Union |
| Height: | 1.79 m |
| Position: | Midfielder |
| Currentclub: | Speranța Nisporeni (Head coach) |
| Years1: | 1992–1997 |
| Years2: | 1996 |
| Years3: | 1997–2001 |
| Years4: | 2001–2002 |
| Years5: | 2003 |
| Years6: | 2003–2005 |
| Years7: | 2005–2006 |
| Years8: | 2007 |
| Years9: | 2007–2008 |
| Years10: | 2008–2009 |
| Years11: | 2009–2010 |
| Years12: | 2010–2011 |
| Clubs1: | Codru Călărași |
| Clubs2: | → MHM-93 Chișinău (loan) |
| Clubs3: | FC Constructorul Chișinău |
| Clubs4: | Zimbru Chișinău |
| Clubs5: | Maccabi Kafr Kanna |
| Clubs6: | Tiligul-Tiras Tiraspol |
| Clubs7: | Okzhetpes |
| Clubs8: | Kairat |
| Clubs9: | Dacia Chișinău |
| Clubs10: | Okzhetpes |
| Clubs11: | Iskra-Stal Rîbnița |
| Clubs12: | FC Milsami Orhei |
| Caps1: | 123 |
| Caps2: | 4 |
| Caps3: | 99 |
| Caps4: | 25 |
| Caps6: | 37 |
| Caps7: | 48 |
| Caps8: | 9 |
| Caps9: | 15 |
| Caps10: | 34 |
| Caps11: | 26 |
| Caps12: | 19 |
| Goals1: | 19 |
| Goals2: | 0 |
| Goals3: | 14 |
| Goals4: | 4 |
| Goals6: | 2 |
| Goals7: | 5 |
| Goals8: | 0 |
| Goals9: | 3 |
| Goals10: | 6 |
| Goals11: | 6 |
| Goals12: | 0 |
| Nationalyears1: | 1998–2001 |
| Nationalteam1: | Moldova |
| Nationalcaps1: | 13 |
| Nationalgoals1: | 0 |
| Manageryears1: | 2012 |
| Manageryears2: | 2013 |
| Manageryears3: | 2014–2016 |
| Manageryears4: | 2017 |
| Manageryears5: | 2017 |
| Manageryears6: | 2020–2021 |
| Managerclubs1: | Rapid Ghidighici |
| Managerclubs2: | Moldova U19 |
| Managerclubs3: | Milsami Orhei |
| Managerclubs4: | Petrocub Hîncești |
| Managerclubs5: | Zimbru Chișinău |
| Managerclubs6: | Speranța Nisporeni |
Iurie Osipenco (born 6 July 1974)[1] is a Moldovan football manager and former player who manages Speranța Nisporeni. From February to June 2017 he was the head coach of Moldovan football club Petrocub Hîncești.