ITPR1 explained

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.^{[1] [2] [3] [4] [5]}

Interactions

ITPR1 has been shown to interact with:

• AHCYL1,^[6]
• CA8,^[7]
• EPB41L1^[8]
• FKBP1A,^{[9] [10]}
• MRVI1,
• PRKG1,^[11]
• RHOA,^[12] and
• TRPC4.^{[13] [14]}

• Caspr2, ^[15]

See also

• Inositol triphosphate
• Inositol triphosphate receptor

References

Further reading

• Stove V, Verhasselt B . Modelling thymic HIV-1 Nef effects . Current HIV Research . 4 . 1 . 57–64 . Jan 2006 . 16454711 . 10.2174/157016206775197583 .
• Joseph SK, Lin C, Pierson S, Thomas AP, Maranto AR . Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells . The Journal of Biological Chemistry . 270 . 40 . 23310–6 . Oct 1995 . 7559486 . 10.1074/jbc.270.40.23310 . free .
• Harnick DJ, Jayaraman T, Ma Y, Mulieri P, Go LO, Marks AR . The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation . The Journal of Biological Chemistry . 270 . 6 . 2833–40 . Feb 1995 . 7852357 . 10.1074/jbc.270.6.2833 . free .
• Wojcikiewicz RJ, Furuichi T, Nakade S, Mikoshiba K, Nahorski SR . Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation . The Journal of Biological Chemistry . 269 . 11 . 7963–9 . Mar 1994 . 10.1016/S0021-9258(17)37145-4 . 8132516 . free .
• Komalavilas P, Lincoln TM . Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase . The Journal of Biological Chemistry . 269 . 12 . 8701–7 . Mar 1994 . 10.1016/S0021-9258(17)37024-2 . 8132598 . free .
• Cameron AM, Steiner JP, Roskams AJ, Ali SM, Ronnett GV, Snyder SH . Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux . Cell . 83 . 3 . 463–72 . Nov 1995 . 8521476 . 10.1016/0092-8674(95)90124-8 . 11594556 . free .
• Yan J, Khanna KK, Lavin MF . Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation . International Journal of Radiation Biology . 69 . 5 . 539–46 . May 1996 . 8648241 . 10.1080/095530096145544 .
• Quinton TM, Dean WL . Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets . Biochemical and Biophysical Research Communications . 224 . 3 . 740–6 . Jul 1996 . 8713116 . 10.1006/bbrc.1996.1093 .
• Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH . FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain . The Journal of Biological Chemistry . 272 . 44 . 27582–8 . Oct 1997 . 9346894 . 10.1074/jbc.272.44.27582 . free .
• Deelman LE, Jonk LJ, Henning RH . The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor . Gene . 207 . 2 . 219–25 . Jan 1998 . 9511764 . 10.1016/S0378-1119(97)00630-6 . 265105806 .
• Martin C, Chapman KE, Seckl JR, Ashley RH . Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum . Neuroscience . 85 . 1 . 205–16 . Jul 1998 . 9607712 . 10.1016/S0306-4522(97)00612-X . 25634042 .
• Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF . Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors . Neuron . 21 . 4 . 717–26 . Oct 1998 . 9808459 . 10.1016/S0896-6273(00)80589-9 . 2851554 . free .
• Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I, Mignery G, Zhu X, Birnbaumer L, Muallem S . Functional interaction between InsP3 receptors and store-operated Htrp3 channels . Nature . 396 . 6710 . 478–82 . Dec 1998 . 9853757 . 10.1038/24890 . 1998Natur.396..478K . 4423316 .
• Lin P, Yao Y, Hofmeister R, Tsien RY, Farquhar MG . Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi . The Journal of Cell Biology . 145 . 2 . 279–89 . Apr 1999 . 10209024 . 2133108 . 10.1083/jcb.145.2.279 .
• Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P . Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta . Nature . 404 . 6774 . 197–201 . Mar 2000 . 10724174 . 10.1038/35004606 . 2000Natur.404..197S . 205004996 .
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proceedings of the National Academy of Sciences of the United States of America . 97 . 7 . 3491–6 . Mar 2000 . 10737800 . 16267 . 10.1073/pnas.97.7.3491 . 2000PNAS...97.3491D . free .
• Mayne M, Holden CP, Nath A, Geiger JD . Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages . Journal of Immunology . 164 . 12 . 6538–42 . Jun 2000 . 10843712 . 10.4049/jimmunol.164.12.6538 . free .
• Tanimura A, Tojyo Y, Turner RJ . Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins . The Journal of Biological Chemistry . 275 . 35 . 27488–93 . Sep 2000 . 10874040 . 10.1074/jbc.M004495200 . free .

External links

• • GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 15

Notes and References

1. Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guénet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T . Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization . The Biochemical Journal . 302 . Pt 3 . 781–90 . Sep 1994 . 7945203 . 1137299 . 10.1042/bj3020781.
2. Nucifora FC, Li SH, Danoff S, Ullrich A, Ross CA . Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant . Brain Research. Molecular Brain Research . 32 . 2 . 291–6 . Sep 1995 . 7500840 . 10.1016/0169-328X(95)00089-B . free .
3. van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB . Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans . PLOS Genetics . 3 . 6 . e108 . Jun 2007 . 17590087 . 1892049 . 10.1371/journal.pgen.0030108 . free .
4. Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y . Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16 . Journal of Medical Genetics . 45 . 1 . 32–5 . Jan 2008 . 17932120 . 10.1136/jmg.2007.053942 . 7730102 .
5. Web site: Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1.
6. Ando H, Mizutani A, Matsu-ura T, Mikoshiba K . IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor . The Journal of Biological Chemistry . 278 . 12 . 10602–12 . Mar 2003 . 12525476 . 10.1074/jbc.M210119200 . free .
7. Hirota J, Ando H, Hamada K, Mikoshiba K . Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1 . The Biochemical Journal . 372 . Pt 2 . 435–41 . Jun 2003 . 12611586 . 1223404 . 10.1042/BJ20030110 .
8. Maximov A, Tang TS, Bezprozvanny I . Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons . Molecular and Cellular Neurosciences . 22 . 2 . 271–83 . Feb 2003 . 12676536 . 10.1016/s1044-7431(02)00027-1. 2317354 .
9. MacMillan D, Currie S, Bradley KN, Muir TC, McCarron JG . In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin . Journal of Cell Science . 118 . Pt 23 . 5443–51 . Dec 2005 . 16278292 . 10.1242/jcs.02657 . free .
10. Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH . FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain . The Journal of Biological Chemistry . 272 . 44 . 27582–8 . Oct 1997 . 9346894 . 10.1074/jbc.272.44.27582. free .
11. Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P . Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta . Nature . 404 . 6774 . 197–201 . Mar 2000 . 10724174 . 10.1038/35004606 . 2000Natur.404..197S . 205004996 .
12. Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB . RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability . The Journal of Biological Chemistry . 278 . 35 . 33492–500 . Aug 2003 . 12766172 . 10.1074/jbc.M302401200 . free .
13. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF . Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors . Cell . 114 . 6 . 777–89 . Sep 2003 . 14505576 . 10.1016/s0092-8674(03)00716-5. 10552676 . free .
14. Mery L, Magnino F, Schmidt K, Krause KH, Dufour JF . Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors . FEBS Letters . 487 . 3 . 377–83 . Jan 2001 . 11163362 . 10.1016/s0014-5793(00)02362-0. 44945442 . free . 2001FEBSL.487..377M .
15. Argent L, Winter F, Prickett L, Carrasquero-Ordaz M, Olsen AL, Kramer H, Lancaster E, Becker EB . Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulatesPurkinje cell morphology . The Journal of Biological Chemistry . 295 . 36 . 12716–26 . Sep 2020 . 32675284 . 10.1074/jbc.RA120.012655 . 7476715 . free .