| Itaquai River | |
| Pushpin Map: | Brazil |
| Source1 Location: | Amazonas state |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Itaquai River is a river of the upper Amazon Basin. It forms the eastern boundary of Atalaia do Norte municipality in the Amazonas state of north-western Brazil. Its main tributary is the Rio Branco. Downstream it joins the Ituí River to form the upper Solimões.