| Itaparaná River | |
| Pushpin Map: | Brazil |
| Pushpin Map Caption: | Mouth location in Brazil |
| River System: | Purus River |
| Source1 Location: | Amazonas state |
| Mouth Coordinates: | -5.7176°N -63.309°W |
| Basin Size: | 19132.7km2[1] |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
| Length: | 370km (230miles) |
| Discharge1 Avg: | 355.124m3/s[2] |
The Itaparaná River is a river of Amazonas state in north-western Brazil.It is a tributary of the Ipixuna River.
The river flows through the Purus-Madeira moist forests ecoregion in its upper reaches.It flows through the Purus várzea ecoregion, where it joins the Ipixuna shortly before that river joins the Purus River.