| Isyesye | |
| Native Name: | Kata ya Isyesye |
| Native Name Lang: | sw |
| Settlement Type: | Ward |
| Pushpin Map: | Tanzania |
| Coordinates: | -8.893°N 33.504°W |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Name1: | Mbeya Region |
| Subdivision Type2: | District |
| Subdivision Name2: | Mbeya Urban |
| Subdivision Type3: | Ward |
| Subdivision Name3: | Isyesye |
| Population As Of: | 2016 |
| Population Total: | 8784 |
| Population Density Km2: | auto |
| Postal Code: | 53127 |
| Postal Code Type: | Postcode |
| Timezone: | EAT |
| Utc Offset: | +3 |
Isyesye is an administrative ward in the Mbeya Urban district of the Mbeya Region of Tanzania. In 2016 the Tanzania National Bureau of Statistics report there were 8,784 people in the ward, from 7,970 in 2012.
The ward has 3 neighborhoods Mwantengule, RRM, and Vingunguti.