Istiblennius colei is a species of combtooth blenny found in the western Pacific Ocean, around the Philippines. Males of this species can reach a maximum of 11.8cm (04.6inches) SL, while females reach a maximum of 10.3cm (04.1inches) SL. The specific name of this blenny honours Howard I. Cole (1892-1966) who was the Chief Chemist for the Philippine Health Service at the leper colony on Culion Island, Philippines, which is the type locality.[1]