| Official Name: | Issele-Uku |
| Pushpin Map: | Nigeria |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Nigeria |
| Subdivision Type: | Country |
| Subdivision Name: |  Nigeria |
| Subdivision Type1: | State |
| Subdivision Name1: | Delta State |
| Subdivision Type2: | Local Government Area |
| Subdivision Name2: | Aniocha North |
| Leader Title: | Obi |
| Leader Name: | Agbogidi Obi Nduka (MNSE) |
| Leader Title1: | HRH for places with, say, both a mayor and a city manager --> |
| Unit Pref: | Imperial |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Timezone: | WAT |
| Utc Offset: | +1 |
| Coordinates: | 6.32°N 6.4768°W |
| Postal Code Type: | Postcode |
| Postal Code: | 320110 |
Issele-uku is a town in Nigeria's Delta State and headquarters for the Local Government Area of Aniocha North.[1] It is also the Episcopal See of the Bishop of the Roman Catholic Diocese of Issele-Uku. It has its own post office and is served by the nearby new Asaba International Airport.
Issee-Uku is Anioma town in present-day Delta State.[2] The Issele-uku Association of North America has written a brief history of this area including an explanation of the origin of the name of the city. Annabelle's village.