| Issam Merdassi | |
| Birth Date: | 1981 3, df=yes |
| Birth Place: | Sfax, Tunisia |
| Position: | Defender |
| Currentclub: | AS Rejiche (manager) |
| Years1: | 2002–2009 |
| Years2: | 2007–2008 |
| Years3: | 2009–2011 |
| Years4: | 2011–2013 |
| Clubs1: | CS Sfaxien |
| Clubs2: | → Al-Nassr (loan) |
| Clubs3: | BSC Young Boys |
| Clubs4: | Misr El Makasa |
| Caps3: | 20 |
| Goals3: | 0 |
| Nationalyears1: | 2006 |
| Nationalteam1: | Tunisia |
| Nationalcaps1: | 2 |
| Nationalgoals1: | 0 |
| Manageryears1: | 2020–2021 |
| Managerclubs1: | Sfax Railways Sports |
| Manageryears2: | 2021– |
| Managerclubs2: | AS Rejiche |
Issam Merdassi (Arabic: عصام المرداسي, born 16 March 1981) is a Tunisian footballer.
Merdassi played until 2006 for CS Sfaxien then went on loan to Saudi Al-Nassr before returning to CS Sfaxien for one season 2008-2009 and finally he was transferred to BSC Young Boys in summer 2009.
He was a member of the Tunisian 2004 Olympic football team, who exited in the first round, finishing third in group C, behind group and gold medal winners Argentina and runners-up Australia.[1]
After managing Sfax Railways Sports, he was appointed manager of AS Rejiche in 2021.[2]