| Issé | |
| Native Name: | (Gallo) |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason issé.svg |
| Arrondissement: | Châteaubriant-Ancenis |
| Canton: | Châteaubriant |
| Insee: | 44075 |
| Postal Code: | 44520 |
| Mayor: | Jean-Marc Lalloué[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Châteaubriant-Derval |
| Coordinates: | 47.6247°N -1.45°W |
| Elevation Min M: | 22 |
| Elevation Max M: | 76 |
| Area Km2: | 38.66 |
Issé (in French pronounced as /ise/; Gallo: Isae, Breton: Izeg) is a commune on the banks of the river Don in the Loire-Atlantique department in western France. It is situated 10 km southeast of Châteaubriant.
The train station reopened in 2014, serving tram-trains from the Pays de la Loire. The narrow gauge railway Issé–Abbaretz was an approximately 20km (10miles) long Decauville railway with a gauge of between the open-cast iron ore mines near Le Houx and the railway stations of Issé and Abbaretz, which was mainly in operation 1913–1922 and 1928–1930.