IsrM small RNA explained

IsrM sRNA
Rfam:	RF02763
Tax Domain:	Bacteria
Go:	,

The IsrM RNA is a small non-coding RNA discovered in Salmonella pathogenicity island, which is not found in E.coli.^[1] It is important for invasion of epithelial cells, intracellular replication inside macrophages, virulence and colonisation in mice. It targets the SopA and HilE mRNAs, virulence factors essential for bacterial invasion. It is a first pathogenicity island-encoded sRNA shown to be directly involved in Salmonella pathogenesis.^[2]

Notes and References

1. Padalon-Brauch G, Hershberg R, Elgrably-Weiss M, Baruch K, Rosenshine I, Margalit H, Altuvia S . Small RNAs encoded within genetic islands of Salmonella typhimurium show host-induced expression and role in virulence . Nucleic Acids Research . 36 . 6 . 1913–1927 . April 2008 . 18267966 . 2330248 . 10.1093/nar/gkn050 . Hanah Margalit .
2. Gong H, Vu GP, Bai Y, Chan E, Wu R, Yang E, Liu F, Lu S . A Salmonella small non-coding RNA facilitates bacterial invasion and intracellular replication by modulating the expression of virulence factors . PLOS Pathogens . 7 . 9 . e1002120 . September 2011 . 21949647 . 3174252 . 10.1371/journal.ppat.1002120 . free .