Isovaleramide Explained

Isovaleramide is an organic compound with the formula (CH3)2CHCH2C(O)NH2. The amide derived from isovaleric acid, it is a colourless solid.

Occurrence and biological activity

Isovaleramide is a constituent of valerian root.

In humans, it acts as a mild anxiolytic at lower doses and as a mild sedative at higher dosages.[1] Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver alcohol dehydrogenases and has a reported of greater than 400 mg/kg when administered intraperitoneally in mice.[2]

It is a positive allosteric modulator of the GABAA receptor, similarly to isovaleric acid.[3]

Notes and References

  1. US. 5506268. 1996-04-09. Use of isovaleramide as a mild anxiolytic and sedative agent. NPS Pharmaceuticals Inc.. Balandrin. Manuel F.. Van Wagenen. Bradford C..
  2. European Journal of Medicinal Chemistry . 10 . 1975 . 453–462 . Taillandier, Georges . Benoit-Guyod, Jean L. . Boucherle, Andre . Broll, Madeleine . Eymard, Pierre . Dipropylacetic series. XII. Anticonvulsant branched aliphatic acids and alcohols . 5.
  3. Giraldo SE, Rincón J, Puebla P, Marder M, Wasowski C, Vergel N, Guerrero MF . [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii] . es. Biomedica . 30 . 2 . 245–50 . 2010 . 20890571 . 10.7705/biomedica.v30i2.187. free . 11336/18247 . free .

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