Isosakuranetin Explained

Isosakuranetin, an O-methylated flavonoid, is the 4'-methoxy derivative of naringenin, a flavanone. Didymin, a disaccharide of isosakuranetin, occur e.g. in sweet orange, blood orange and mandarin.^[1] Isosakuranetin is a potent inhibitor of TRPM3 channels.^[2]

Glycosides

• Poncirin is the 7-O-neohesperidoside of isosakuranetin.
• Didymin is the 7-O-rutinoside of isosakuranetin

Notes and References

1. "Polyphenols in Human Health and Disease"
2. Straub. Isabelle. Krügel. Ute. Mohr. Florian. Teichert. Jens. Rizun. Oleksandr. Konrad. Maik. Oberwinkler. Johannes. Schaefer. Michael. November 2013. Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. Molecular Pharmacology. 84. 5. 736–750. 10.1124/mol.113.086843. 1521-0111. 24006495.