Isoquercetin Explained

Isoquercetin, isoquercitrin or isotrifoliin[1] is a flavonoid, a type of chemical compound. It is the 3-O-glucoside of quercetin. Isoquercitrin can be isolated from various plant species including Mangifera indica (mango)[2] and Rheum nobile (the Noble rhubarb). It is also present in the leaves of Annona squamosa, Camellia sinensis (tea).[3] [4] and Vestia foetida[5]

Spectral data

The lambda-max for isoquercetin is 254.8 and 352.6 nm.

Potential clinical uses

Isoquercetin is presently being investigated for prevention of thromboembolism in selected cancer patients[6] and as an anti-fatigue agent in kidney cancer patients treated with sunitinib.[7]

There is a single case report of its use in the successful treatment of prurigo nodularis, a difficult to treat pruritic eruption of the skin.[8]

However it belongs to the PAINS (Pan-assay interference compounds) categories of chemicals.[9]

See also

Notes and References

  1. Web site: Isoquercetin . . 2018-09-11.
  2. Singh UP, Singh DP, Singh M, etal . Characterization of phenolic compounds in some Indian mango cultivars . International Journal of Food Sciences and Nutrition . 55 . 2 . 163–9 . 2004 . 14985189 . 10.1080/09637480410001666441.
  3. Panda S, Kar A. Antidiabetic and antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin-3-O-glucoside . BioFactors . 2007 . 31 . 3-4 . 201–210 . 18997283 . 10.1002/biof.5520310307.
  4. 10.1021/jf020926l . Simultaneous determination of all polyphenols in vegetables, fruits, and teas . 2003 . Sakakibara . H . Honda . Y . Nakagawa . S . Ashida . H . Kanazawa . K . Journal of Agricultural and Food Chemistry . 51 . 3 . 571–81 . 12537425.
  5. C. Brevis, M. Quezada, P. Bustamante, L. Carrasco, A. Ruiz, S. Donoso, Huevil (Vestia foetida) poisoning of cattle in Chile The Veterinary record 156(14):452-3 May 2005
  6. https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/view?cdrid=763277 NCT02195232
  7. https://clinicaltrials.gov/ct2/show/study/NCT02446795#contacts NCT02446795
  8. Use of Isoquercetin in the Treatment of Prurigo Nodularis . November 2017 . 16 . 11 . 1156–1158 . Journal of Drugs in Dermatology . Christine M. . Pennesi . John . Neely . Ames G. . Marks Jr. . S. . Alison Basak.
  9. Nature . 2014. 513. 7519 . 481–483 . Chemistry: Chemical con artists foil drug discovery . J Baell . M A Walters . 10.1038/513481a . amp . 25254460 . free .

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